PEG包裹纳米金粒子作为新型CT造影剂的初步探索  

Preliminary Research on Polyethylene Glycol-coated Gold-nanoparticles as a Noval CT Contrast Agent

作　　者：张雅颖 侯雨希 刘日 尹伟 彭雯佳 弓静 FAN Chengqi ZHANG Yaying;HOU Yuxi;LIU Ri;YIN Wei;FAN Chengqi;PENG Wenjia;GONG Jing(Department of Radiology,Changhai Hospital,Navy Medical University,Shanghai,200433;Department of Radiology,Shanghai Fourth People's Hospital,Affi liated to,Tongji University,Shanghai,200434)

机构地区：[1]海军军医大学第一附属医院(长海医院)放射科,上海200433 [2]同济大学附属上海市第四人民医院放射科,上海200434 [3]不详

出　　处：《生物医学工程学进展》2022年第1期1-6,共6页Progress in Biomedical Engineering

基　　金：国家自然科学基金(81400368)。

摘　　要：目的探究聚乙二醇包裹纳米金粒子(PEGlatedAuNPs)作为新型CT造影剂的可行性。方法将7个不同浓度的PEGlatedAuNPs与非离子型碘造影剂碘普罗胺(Iopromide)进行体外CT扫描,比较衰减系数和成像能力;通过皮下注入和静脉注射方式进行动物体内CT的扫描,评估体内各脏器的强化特点。结果相同浓度的PEGlatedAuNPs较Iopromide衰减系数高,且随着浓度的增加两者CT值差异越来越大;在皮下形态稳定,能长时间停留而不易被吸收;在SD大鼠体内相容性较好;在体内循环时间长,主要经肝脏代谢。结论PEGlatedAuNPs是一种理想的CT分子显像造影剂。Objective To explore the feasibility of polyethylene glycol-coated gold-nanoparticles(PEGlatedAuNPs)as a new CT contrast agent.Methods In vitro CT scanning was performed on seven different concentrations of PEGelatedAuNPs and non-ionic iodine contrast agent iopromide,and the attenuation coefficient and imaging ability were compared.In vivo CT scanning was also performed after the animals were subcutaneously injected and intravenous injected with PEGelatedAuNPs and non-ionic iodine contrast agent iopromide to evaluate the enhancement characteristics of various organs in vivo.Results The attenuation coefficient of PEGelatedAuNPs was higher than that of iopromide when the agents were at the same concentration.In addition,the difference of CT values between PEGelatedAuNPs and iopromide increased with the increase of the agent concentration.The PEGelatedAuNPs is stable under the skin and can stay for a long time without being easily absorbed.The PEGelatedAuNPs has good biocompatibility in SD rats,possesses a long circulation time in the body and is mainly metabolized by the liver.Conclusion PEGlatedAuNPs is an ideal CT molecular imaging contrast agent.

关 键 词：金纳米粒子 CT造影剂 

分 类 号：R318[医药卫生—生物医学工程] TP391[医药卫生—基础医学]