癌症诊疗一体化荧光成像纳米探针的研究进展  

Research advances of fluorescence imaging-based cancer theranostic nanoprobes

作　　者：李兆阁 胡贵珍 郭文政 聂亚敏 周艳梅[1] LI Zhaoge;HU Guizhen;GUO Wenzheng;NIE Yamin;ZHOU Yanmei(Henan Joint International Research Laboratory of Environmental Pollution Control Materials,College of Chemistry and Chemical Engineering,Henan University,Kaifeng 475004,Henan,China)

机构地区：[1]河南大学化学化工学院,河南省环境污染控制材料国际联合实验室,河南开封475004

出　　处：《化学研究》2022年第2期103-113,共11页Chemical Research

基　　金：国家自然科学基金资助项目(21978069)。

摘　　要：基于新型纳米材料构建的癌症诊疗一体化平台,将诊断探针和治疗试剂结合在一个功能化的纳米材料上,实现癌症的诊断、治疗和疗效监控等功能于一体,不仅能够实现癌症的成像和治疗,而且可以实现对治疗效果的实时检测,为癌症的早期诊断和精准治疗提供一个全新的多功能诊治平台。基于荧光成像(FLI)的纳米材料诊疗一体化平台,具有灵敏度高、选择性好、原位可视化观测、非侵入性强等优点,受到了广泛关注。本文对基于多种纳米材料的FLI癌症诊疗一体化探针进行归纳总结,有助于对纳米材料在诊疗一体化中的广阔应用。The cancer theranostic nanoprobes based on new nanomaterials combines diagnostic probes and therapeutic reagents on a functional nanomaterial to realize the integration of cancer diagnosis,treatment,and curative effect monitoring.It can realize cancer imaging and treatment,and real-time detection of treatment effects,thus providing a brand-new multifunctional diagnosis and treatment platform for early diagnosis and precise treatment of cancer.The integrated platform for diagnosis and treatment of nano-materials based on fluorescence imaging(FLI)has the advantages of high sensitivity,good selectivity,in-situ visual observation,and strong non-invasiveness,and has received extensive attention.This paper summarizes the integration of fluorescent imaging cancer diagnosis and treatment probes based on a variety of nanomaterials,which is helpful for the broad application of nanomaterials in the integration of re-diagnosis and treatment.

关 键 词：诊疗一体化 荧光成像 纳米材料 

分 类 号：R445[医药卫生—影像医学与核医学]