金纳米簇化学发光体外生物检测应用研究进展  

Research Progresses on Chemiluminescent Gold NanoclustersApplied in Biological in vitro Detection

作　　者：夏天昊 王云鹏[1] 戴晓茹 凌世生 陈东 乔旭升[1] 樊先平[1] XIA Tian-hao;WANG Yun-peng;DAI Xiao-ru;LING Shi-sheng;CHEN Dong;QIAO Xu-sheng;FAN Xian-ping(State Key Laboratory of Silicon Materials&School of Materials Science and Engineering,Zhejiang University,Hangzhou 310027,China;Assure Tech.(Hangzhou)Co.,LTD.,Hangzhou 310011,China)

机构地区：[1]浙江大学材料科学与工程学院硅材料国家重点实验室,浙江杭州310027 [2]杭州安旭生物科技有限公司,浙江杭州310011

出　　处：《发光学报》2022年第3期314-326,共13页Chinese Journal of Luminescence

基　　金：浙江省“领雁”研发攻关计划(2022C01142)资助项目。

摘　　要：金纳米簇是一种制备工艺简单、具有分子级尺寸和量子效应的新型发光材料,近年来在化学发光检测中得到了广泛应用,特别是较多应用于体外生物检测。本文综述了金纳米簇化学发光(含电化学发光)体系在体外生物检测中的应用进展。首先,阐释了金纳米簇的合成方法、结构、性质及其化学发光基本原理;其次,总结了国内外近年来基于该体系的体外生物检测研究进展,并梳理了改善发光强度和检测灵敏度的已有策略;最后,对金纳米簇化学发光的未来发展趋势进行了展望。Gold nanoclusters are novel luminescent materials with simple preparation method,molecular size and quantum effect,which have been widely applied in chemiluminescence detection in recent years,especially in in vitro biological detection.This article reviews the progress of gold nanoclusters chemiluminescence(including electrochemiluminescence)system in the application of in vitro biological detection.First,the synthesis,structure,properties of gold nanoclusters and the basic principle of chemiluminescence system are introduced and explained theoretically.Next,recent reports are summarized on in vitro biological detection with gold nanoclusters,and strategies in literatures are overviewed and commented on how to improve the luminescent intensity and detection sensitivity.Finally,we give an outlook on the development trend of gold nanoclusters chemiluminescence system.

关 键 词：金纳米簇 化学发光 电化学发光 体外生物检测 

分 类 号：O482.31[理学—固体物理]