血清内皮素-1、一氧化氮及C反应蛋白水平与下肢动脉硬化闭塞症支架植入术后再狭窄的相关性  

Relationships of serum endothelin 1,nitric oxide and C-reactive protein levels with restenosis in patients with loweRextremity arteriosclerosis obliterans afteRstent implantation

作　　者：李立涛 曾桂强 易江枫 LI Litao;ZENG Guiqiang;YI Jiangfeng(Department of Interventional VasculaRSurgery,Heyuan Hospital of Guangdong Provincial People′s Hospital,Heyuan,Guangdong,517000)

机构地区：[1]广东省人民医院河源医院介入血管外科,广东河源517000

出　　处：《实用临床医药杂志》2022年第3期9-12,共4页Journal of Clinical Medicine in Practice

摘　　要：目的探讨血清内皮素-1(ET-1)、一氧化氮(NO)及C反应蛋白(CRP)水平与下肢动脉硬化闭塞症(ASO)患者支架植入术后再狭窄的关系。方法回顾性分析行支架植入术治疗的173例ASO患者的临床资料,根据术后1个月是否出现再狭窄将其分为再狭窄组22例和未狭窄组151例。比较2组患者的临床资料,分析再狭窄的危险因素,并采用受试者工作特征(ROC)曲线分析血清ET-1、NO、CRP水平对ASO患者支架植入术后再狭窄的诊断价值。结果再狭窄组吸烟、糖化血红蛋白(HbA1c)、ET-1、NO、CRP水平高于未狭窄组,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,吸烟、HbA1c≥6%、ET-1≥60 g/L、NO≥32μmol/L、CRP≥20 mg/L为ASO患者支架植入术后再狭窄的独立危险因素(P<0.05);ROC曲线显示,血清ET-1、NO、CRP联合诊断ASO患者支架植入术后再狭窄的曲线下面积大于单独检测,差异有统计学意义(P<0.05)。结论ASO支架植入术后再狭窄患者血清ET-1、NO、CRP水平高表达,可能参与术后再狭窄的发生发展。Objective To study the relationships of serum endothelin 1(ET-1),nitric oxide(NO)and C-reactive protein(CRP)levels with restenosis in patients with loweRextremity arteriosclerosis obliterans(ASO)afteRstent implantation.Methods A retrospective analysis was performed on the clinical data of 173 patients with ASO treated with stent implantation.The patients were divided into restenosis group(n=22)and non-stenosis group(n=151)according to the presence oRabsence of restenosis at one month afteRoperation.The clinical data of the two groups were compared,and the risk factors were analyzed.ReceiveRoperating characteristic(ROC)curve was used to analyze the value of serum ET-1,NO and CRP levels in the diagnosis of restenosis in patients with ASO afteRstent implantation.Results The proportion of patients with smoking history,levels of glycated hemoglobin(HbA1c),ET-1,NO and CRP in the restenosis group were higheRthan those in the non-stenosis group(P<0.05).Logistic multivariate regression analysis showed that smoking and HbA1c≥6%,ET-1≥60 g/L,NO≥32μmol/L and CRP≥20 mg/L were independent risk factors foRrestenosis afteRSTENT implantation in ASO patients(P<0.05).ROC curve showed that the area undeRthe curve of combined diagnosis of serum ET-1,NO and CRP levels foRrestenosis in patients with ASO afteRstent implantation was higheRthan that of single detection(P<0.05).Conclusion Serum ET-1,NO and CRP levels are higheRin ASO patients with restenosis afteRstent implantation,which indicates that these indicators may be involved in the occurrence and development of restenosis.

关 键 词：下肢动脉硬化闭塞症 支架植入 再狭窄 内皮素-1 一氧化氮 C反应蛋白 

分 类 号：R658.3[医药卫生—外科学] R543.5[医药卫生—临床医学]