PM_(2.5)致免疫调节紊乱在动脉粥样硬化发生、发展的研究进展  

Advances in PM_(2.5)-induced immune regulation disorder in the occurrence and development of atherosclerosis

作　　者：李娜(综述) 许商成 尹扬光(审校) LI Na;XU Shangcheng;YIN Yangguang(School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211112,China;Department of Cardiology,Chongqing Prevention and Treatment Center for Occupational Diseases,Chongqing 400060,China;Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning,Chongqing Prevention and Treatment Center for Occupational Diseases,Chongqing 400060,China)

机构地区：[1]南京医科大学公共卫生学院,南京211112 [2]重庆市职业病防治院心内科,400060 [3]重庆市职业病防治院职业病防治与中毒救治重庆市重点实验室,400060

出　　处：《重庆医学》2022年第6期1060-1064,1069,共6页Chongqing medicine

基　　金：国家自然科学基金项目(82073523);重庆市自然科学基金杰出青年科学基金(cstc2020jcyj-jq0106);重庆市医学科研项目(20143023)。

摘　　要：细颗粒物(PM_(2.5))是指大气中空气动力学直径≤2.5μm的颗粒物,是雾霾的重要组成部分。流行病学研究和动物实验均表明,PM_(2.5)的暴露与动脉粥样硬化(AS)的发生、发展密切相关。AS作为一种具有自身免疫成分的慢性炎症性疾病,实验研究证明通过免疫调节、抗炎免疫反应可以减轻AS,表明在PM_(2.5)致AS发生、发展的过程中免疫调节紊乱起着重要的作用。该文基于现有的文献资料,结合相关体内、体外实验研究,综合探讨并总结PM_(2.5)致免疫调节紊乱在AS中的作用。Fine particulate matter(PM_(2.5))refers to particulate matter with an aerodynamic diameter of 2.5μm or less in the atmosphere,which is the main component of haze.Epidemiological studies and animal experiments have shown that PM_(2.5) exposure is closely related to the occurrence and development of atherosclerosis(AS).AS is a chronic inflammatory disease with autoimmune components.Experimental studies have proved that atherosclerosis can be alleviated by immunomodulatory and anti-inflammatory immune responses.These results suggest that immunomodulatory disorder plays an important role in the occurrence and development of PM_(2.5) induced atherosclerosis.Based on the existing literature and related in vivo and in vitro experimental studies,this paper comprehensively discusses and summarizes the role of PM_(2.5)-induced immune regulation disorder in atherosclerosis.

关 键 词：细颗粒物 动脉粥样硬化 免疫调节紊乱 炎性反应 内皮损伤 综述 

分 类 号：R714.252[医药卫生—妇产科学]