Impact of polyethylene glycol 400/propylene glycol/hydroxypropyl-guar and 0.1%sodium hyaluronate on postoperative discomfort following cataract extraction surgery:a comparative study  

作　　者：Georgios Labiris Panagiota Ntonti Haris Sideroudi Vassilios Kozobolis 

机构地区：[1]Department of Ophthalmology,University Hospital of Alexandroupolis,68100 Dragana,Alexandroupolis,Greece [2]Eye Institute of Thrace,Alexandroupolis,Greece

出　　处：《Eye and Vision》2017年第1期59-65,共7页眼视光学杂志（英文）

摘　　要：Background:Universal postoperative guidelines for cataract extraction surgery are yet to be introduced.Artificial tears are gaining popularity as an additional integral component of the postoperative regime.The primary objective of this study was to explore the impact of two prevalent artificial tear preparations on postoperative discomfort following cataract extraction surgery.Methods:A total of 180 patients that underwent cataract extraction surgery were randomly divided into three groups according to their postoperative regime:a)Study group 1(SG1)received a fixed combination of tobramycin and dexamethasone(FCTD)quid for 3 weeks and,additionally polyethylene glycol 400/propylene glycol/hydroxypropyl-guar quid,for 6 weeks,b)Study group 2(SG2)received FCTD quid for 3 weeks and,additionally 0.1%sodium hyaluronate provided in the COMOD^(®)device quid,for 6 weeks,and,c)Control Group(CG)received only FCTD quid for 3 weeks.The following indexes were evaluated at three postoperative checkpoints:1)Subjective discomfort index(SDI)derived from four direct 10-scale Likert-type questions that were addressed to the patient and pertained to:a)foreign body sensation(FBS),b)blinking discomfort(BD),c)stinging sensation(SS),d)tearing sensation(TS),2)Tear break-up time(TBUT),3)Central corneal thickness(CCT)and,4)Central Corneal Sensitivity(CCS).Results:Both groups showed increased CCT values at the first examination point and reduced CCS values at all examination points.Furthermore,both SGs had better TBUT times at all examination points compared to CG(CG:8.86±1.08,SG1:9.59±1.45,CG2:9.45±1.33,p<0.05).BD was significantly better in both SGs only at the 1^(st) week of examination,while SDI values were better until the 3^(rd) week and only borderline better at 6^(th) week.Lastly,no significant differences were detected between SGs,regarding all parameters,at all examination points.Conclusion:Polyethylene glycol 400/propylene glycol/hydroxypropyl-guar and 0.1%sodium hyaluronate provided in the COMOD^(®)device seem to be equally e

关 键 词：CATARACT Postoperative regimen Artificial tears Surface discomfort index Systane Hylocomod 

分 类 号：O63[理学—高分子化学]