碳硫双手性邻苯二甲酰类鱼尼丁受体杀虫剂研究进展  

Research progress of dual chiral carbon-sulfur phthaloyl ryanodine receptor insecticides

作　　者：李林珊 谢伟彬 郑占英[1] 李正名[1] 周莎[1] LI Linshan;XIE Weibin;ZHENG Zhanying;LI Zhengming;ZHOU Sha(National Pesticidal Enginerring Center,Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300110,China)

机构地区：[1]南开大学元素有机化学研究所农药国家工程研究中心,天津300110

出　　处：《世界农药》2022年第3期21-26,52,共7页World Pesticide

基　　金：国家重点研究开发计划(2018YFD0200100);国家自然科学基金(No.21602118)。

摘　　要：近年来在开展具有新型作用机制的鱼尼丁受体杀虫剂创制研究中,笔者课题组首次报道了新型碳硫双手性邻苯二甲酰类鱼尼丁受体杀虫剂的设计合成以及其生物活性研究,所总结的构效关系对这类生态友好的杀虫剂的创制研究具有一定的指导意义。Our group made some progress on the innovation of novel ryanodine receptor insecticides.It was the first time to describe phthaloyl ryanodine receptors containing carbon-sulfur dual chiral with their insecticidal activity against armyworm and diamondback moth.The impact of carbon and sulfur chirality on bioactivity was systemically studied.The research work will be valuable for further exploration,and its structural features,chiral chemistry and structure-activity relationship could be used as reference for innovation of novel RyR regulators in future.

关 键 词：碳硫双手性 邻苯二甲酰 鱼尼丁受体 绿色杀虫剂 

分 类 号：TQ450[化学工程—农药化工]