抗苗勒管激素水平与非优质囊胚移植潜力的相关性研究  

Correlation between AMH level and non high quality blastocyst transfer potential

作　　者：马小红[1] 裴利国[1] 何盛昱 李晓荣[1] 徐仙[1] 吴昕[1] 马丽丽[1] 陈琰[1] MA Xiao-Hong;PEI Li-Guo;HE Sheng-Yu(The Center for Reproductive Medicine,General Hospital of Ningxia Medical University/Key Laboratory of Reproduction and Genetics in Ningxia/Key Laboratory of Fertility Maintenance,Ministry of Education,Yinchuan,Ningxia 750004,China)

机构地区：[1]宁夏医科大学总医院生殖医学中心宁夏生殖与遗传重点实验室生育力保持教育部重点实验室,宁夏银川750004 [2]宁夏第五人民医院石嘴山中心医院妇产科,宁夏石嘴山753200

出　　处：《中国妇幼保健》2022年第5期854-857,共4页Maternal and Child Health Care of China

基　　金：国家自然科学基金(81660806);宁夏回族自治区自然科学基金项目(2018AAC03163)。

摘　　要：目的探讨抗苗勒管激素(AMH)水平与非优质囊胚移植临床结局的关系。方法回顾性分析冷冻胚胎冻融周期移植的240例患者,其中非优质单囊胚移植组129例,非优质双囊胚移植组111例,根据AMH水平分组,AMH<1.5 ng/ml为A组,AMH 1.5~4.5 ng/ml为B组,AMH>4.5 ng/ml为C组。分析3组AMH水平与非优质单囊胚移植、非优质双囊胚移植妊娠结局的相关性。结果在非优质单囊胚移植方案中,3组患者的临床妊娠率分别为30.30%、40.00%、52.17%,虽临床妊娠率随着AMH的升高有上升趋势,但差异无统计学意义(P>0.05);流产率分别30.00%、15.00%、25.00%,差异无统计学意义(P>0.05)。在非优质双囊胚移植方案中,3组患者的临床妊娠率分别为58.33%、50.00%、58.82%,流产率分别42.86%、37.50%、20.00%,妊娠率和流产率比较,差异均无统计学意义(均P>0.05),各组多胎率明显升高。双囊胚移植的临床妊娠率与单囊胚移植比较,差异有统计学意义(P<0.05),两组流产率比较,差异无统计学意义(P>0.05)。结论血清AMH水平在非优质囊胚移植中对妊娠结局的影响不大,AMH水平的高低并不能预估非优质囊胚移植的潜力,但非优质囊胚仍存在较大的移植价值。Objective To investigate the relationship between anti-Mullerian hormone(AMH)level and the clinical outcome of non-quality blastocyst transplantation.Methods A retrospective analysis was performed on 240 patients undergoing freeze-thaw cycle transfer of frozen embryos,including 129 cases in the non-high-quality single blastocyst transfer group and 111 cases in the non-high-quality double blastocyst transfer group.According to the AMH level,AMH<1.5 ng/ml was classified as group A,and AMH 1.5-4.5 ng/ml was classified as group B.AMH>4.5 ng/ml was group C.The correlation between AMH levels and pregnancy outcomes of non-high quality single blastocyst transplantation and non-high quality double blastocyst transplantation was analyzed.Results In the non-high quality single blastocyst transplantation regimen,the clinical pregnancy rates of the 3 groups were 30.30%,40.00% and 52.17%,respectively.Although the clinical pregnancy rates increased with the increase of AMH,the difference was not statistically significant(P>0.05).The abortion rates were 30.00%,15.00% and 25.00%,respectively,with no statistical significance(P>0.05).In the non-high quality double blastocyst transplantation program,the clinical pregnancy rates of the 3 groups were 58.33%,50.00%,58.82%,respectively,and the abortion rates were 42.86%,37.50%,20.00%,respectively.There was no significant difference in pregnancy rate and abortion rate(P>0.05),and the multiple pregnancy rate in each group was significantly increased.The clinical pregnancy rate of double blastocyst transplantation was significantly different from that of single blastocyst transplantation(P<0.05),but there was no significant difference in abortion rate between the two groups(P>0.05).Conclusion Serum AMH level has little effect on pregnancy outcome in non-high quality blastocyst transplantation,and the level of AMH does not predict the potential of non-high quality blastocyst transplantation.However,non-high quality blastocysts still have great transplantation value.

关 键 词：抗苗勒管激素 非优质囊胚 妊娠结局 

分 类 号：R711[医药卫生—妇产科学]