急性失代偿心力衰竭患者血流动力学稳定后应用沙库巴曲缬沙坦的临床疗效  

Clinical Effects of the Application of Sacubatro Valsartan after Acute Hemodynamic Stability of Decompensated Heart Failure

作　　者：荆峰 张明吉 JING Feng;ZHANG Ming-Ji(Internal Medicine-Cardiovascular Department,General Hospital of Anshan Steel Group Company,Anshan 114003,China)

机构地区：[1]鞍钢集团公司总医院心内科,辽宁鞍山114003

出　　处：《中国药物经济学》2022年第2期28-31,共4页China Journal of Pharmaceutical Economics

基　　金：鞍山市科技局项目(2010320001)。

摘　　要：目的探讨沙库巴曲缬沙坦用于血流动力学稳定后急性失代偿心力衰竭患者的治疗作用。方法选取2018年6月至2020年6月鞍钢集团公司总医院收治的300例急性失代偿心力衰竭患者为研究对象,依据血流动力学平稳后药物使用情况将其分为血管紧张素转化酶抑制剂组(ACEI,150例)与沙库巴曲缬沙坦组(ARNI,150例)。比较两组用药前后血常规指标、总蛋白、总胆红素、左心室射血分数、左心室舒张末期内径、肌酐水平以及肾小球清除率。结果 ARNI组与ACEI组治疗有效率为83.33%、74.00%,差异有统计学意义(P<0.05)。用药前后两组血红蛋白、血小板、血细胞比容以及血小板压积水平比较,差异无统计学意义(P>0.05)。用药前后两组患者总蛋白以及总胆红素水平比较差异无统计学意义(P>0.05)。用药后ARNI组左心室射血分数高于ACEI组,左心室舒张末期内径短于ACEI组,差异有统计学意义(P<0.05)。用药前后两组肌酐水平以及肾小球清除率比较差异无统计学意义(P>0.05)。结论将沙库巴曲缬沙坦应用于血流动力学稳定后的急性失代偿心力衰竭病患治疗中,可显著改善其心功能以及左心室重构,对肝肾功能影响较小,可发挥一定干预效果。Objective To explore the therapeutic effect of Sacubatro valsartan in patients with acute decompensated heart failure after hemodynamic stability. Methods 300 patients admitted to the General Hospital of Ansteel Group Corporation from June 2018 to June 2020 with acute decompensated heart failure in our hospital were selected as research samples. According to the early medication after stable hemodynamics, the patients were divided into angiotensin converting enzyme inhibitor group(ACEI, 150 cases) and sacubatro valsartan group(Arni, 150 cases). The blood routine indexes, total protein, total bilirubin, left ventricular ejection fraction, left ventricular end-diastolic diameter, creatinine level and glomerular clearance rate were compared between the 2 groups before and after medication. Results The effective rate of treatment between ARNI group and ACEI group was 83.33% and 74.00%, the difference was statistically significant(P<0.05).Before and after treatment, there was no significant difference in hemoglobin, platelet, hematocrit and platelet hematocrit between the 2 groups(P>0.05). After treatment, there was no significant difference in the levels of total protein and total bilirubin between the 2 groups(P>0.05). After treatment, the left ventricular ejection fraction in Arni group was higher than that in ACEI group, and the left ventricular end diastolic diameter was shorter than that in ACEI group(P<0.05). After treatment, there was no significant difference in creatinine level and glomerular clearance rate between the 2 groups(P>0.05). Conclusion The application of sakubatro valsartan in the treatment of patients with acute decompensated heart failure after stable hemodynamics can significantly improve their cardiac function and left ventricular remodeling, and has little effect on liver and kidney function, which can play a certain intervention effect.

关 键 词：沙库巴曲缬沙坦 血流动力学 心力衰竭 急性失代偿 左心室射血分数 

分 类 号：R541.6[医药卫生—心血管疾病] R972[医药卫生—内科学]