缺氧缺血性脑病新生儿血清sLOX-1、VILIP-1的变化及临床意义  

Changes and clinical significance of serum sLOX-1 and VILIP-1 in neonates with hypoxic ischemic encephalopathy

作　　者：陈晓玲[1] 陈晓君 杨丽霞 邢舒旺 邱成英 CHEN Xiaoling;CHEN Xiaojun;YANG Lixia;XING Shuwang;QIU Chengying(Department of Neonatology,West China Sanya Hospital,Sichuan University,Sanya 572300,China;Department of Pharmacy,West China Sanya Hospital,Sichuan University,Sanya 572300,China)

机构地区：[1]四川大学华西三亚医院新生儿科,572300 [2]四川大学华西三亚医院药剂科,572300

出　　处：《天津医药》2022年第3期310-314,共5页Tianjin Medical Journal

摘　　要：目的探讨缺氧缺血性脑病(HIE)新生儿血清可溶性凝集素样氧化型低密度脂蛋白受体1(sLOX-1)、视椎蛋白样蛋白1(VILIP-1)的变化及临床意义。方法HIE患儿(HIE组)146例,分为轻度组(58例)、中度组(52例)和重度组(36例)。另选取正常新生儿50例为对照组。HIE组分别于出生后24 h(T1)、出生后48 h(T2)、出生后72 h(T3)检测血清sLOX-1、VILIP-1水平,对照组于出生后24 h(T1)进行检测。结果HIE组的5 min Apgar评分、NBNA评分均低于对照组(P<0.05);随时间延续,HIE组血清sLOX-1、VILIP-1水平均降低(P<0.05),与对照组比较,HIE组各时点VILIP-1水平及T1、T2时间点的血清sLOX-1水平均增高(P<0.05)。随时间延续,轻、中及重度组血清sLOX-1、VILIP-1水平均降低,各时间点轻、中及重度组血清sLOX-1、VILIP-1水平依次升高(P<0.05)。HIE患儿血清sLOX-1、VILIP-1与5 min Apgar评分、NBNA评分均呈负相关(P<0.05);血清sLOX-1(AUC=0.784,95%CI:0.702~0.869)、VILIP-1(AUC=0.752,95%CI:0.655~0.847)对HIE均有较高的诊断价值,两者联合诊断时敏感度[0.863(126/146)]和特异度[0.840(42/50)]均有明显提高。结论HIE患者血清sLOX-1、VILIP-1表达水平较高,且其病情越严重表达水平越高,动态监测血清sLOX-1、VILIP-1水平对HIE的早期诊断、病情评估具有重要意义。Objective To investigate the changes and clinical significance of serum soluble lectin like oxidized low density lipoprotein receptor-1(sLOX-1)and vertebral protein like protein-1(VILIP-1)in neonates with hypoxic ischemic encephalopathy(HIE).Methods A total of 146 neonates with HIE were selected as the HIE group.According to the clinical grading standard of HIE,the neonates were divided into the mild group(n=58),the moderate group(n=52)and the severe group(n=36).Another 50 normal neonates were selected as the control group.The serum levels of sLOX-1 and VILIP-1 were detected at 24 h(T1),48 h(T2)and 72 h(T3)after birth in the HIE group,and the control group was detected at 24 h after birth(T1).Results The 5 min Apgar score and NBNA score were significantly lower in the HIE group than those in the control group(P<0.05).Over time,the serum levels of sLOX-1 and VILIP-1 were decreased in the HIE group(P<0.05).Compared with the control group,the serum levels of VILIP-1 at each time point and the serum levels of sLOX-1 at the T1 and T2 time points were increased in the HIE group(P<0.05).Over time,the serum levels of sLOX-1 and VILIP1 were decreased in the mild,moderate and severe groups,and the serum levels of sLOX-1 and VILIP-1 were increased successively at each time point in the mild,moderate and severe groups(P<0.05).Serum levels of sLOX-1 and VILIP-1 were negatively correlated with 5 min Apgar score and NBNA score in neonates with HIE(P<0.05).Serum levels of sLOX-1(AUC=0.784,95%CI:0.702-0.869)and VILIP-1(AUC=0.752,95%CI:0.655-0.847)showed high diagnostic values for HIE.The sensitivity[0.863(126/146)]and the specificity[0.840(42/50)]of the combined detection were significantly improved,and the diagnostic value was further improved.Conclusion The expression levels of serum sLOX-1 and VILIP1 increase in HIE,and their expression levels are related to the severity of the disease.Dynamic monitoring of serum levels of sLOX-1 and VILIP-1 is of great significance for the early diagnosis and disease assessment of HIE.

关 键 词：缺氧缺血 脑 婴儿 新生 疾病 早期诊断 可溶性凝集素样氧化型低密度脂蛋白受体1 视椎蛋白样蛋白1 

分 类 号：R722.12[医药卫生—儿科]