MicroRNA在骨骼发育与修复中的功能研究进展  

Research Progress of MicroRNA in the Development and Repair of Skeleton

作　　者：裴欣 杨天雄 武世瑶 吴尽[1] 刘学东[1] PEI Xin;YANG Tianxiong;WU Shiyao;WU Jin;LIU Xuedong(College of Wildlife and Protected Area,Northeast Forestry University,Harbin Heilongjang 150040)

机构地区：[1]东北林业大学野生动物与自然保护地学院,黑龙江哈尔滨150040

出　　处：《中国科技纵横》2022年第3期147-149,共3页China Science & Technology Overview

基　　金：中央高校基本科研业务费专项资金(2572019BE01)。

摘　　要：MicroRNA(miRNA)在哺乳动物体内不仅能直接调控基因表达,还可通过靶基因间接参与多种信号通路的调控。miRNA参与骨骼生长、发育和修复过程,甚至引起骨骼发育修复的异常,导致骨疾病发生。改变相关miRNA及其靶基因的表达水平,可调节骨代谢,从而对骨疾病起到治疗作用。现对miRNA在动物骨骼发育与修复的功能研究进行综述,以期完善骨代谢相关生理过程机制,为骨相关疾病的治疗提供新的思路。MicroRNA(miRNA)is a kind of non-coding small RNA.In mammals,miRNA can not only directly regulate gene expression,but also indirectly participate in the regulation of multiple signaling pathways through its target genes.MiRNA related to bone cells will participate in.the process of skeleton development and repair,leading to the occurrence of bone diseases.However,changing the expression levels of miRNA and its target genes can play a therapeutic role in bone diseases.This paper reviews the research progress of miRNA on skeleton development and repair in animals,in order to provide new ideas for the treatment of bone related diseases.

关 键 词：MICRORNA 成骨细胞 破骨细胞 骨骼发育 骨骼修复 

分 类 号：Q445[生物学—生理学]