抗骨质疏松胶囊对绝经后骨质疏松症患者骨密度及骨代谢生化指标的影响  

Influence of Anti-osteoporosis Capsules on Bone Mineral Density and Bone Metabolism Biochemical Markers in Patients with Postmenopausal Osteoporosis

作　　者：熊巍 王贵梅[1] XIONG Wei;WANG Guimei(Sichuan Provincial Orthopedic Hospital,Chengdu 610041,China)

机构地区：[1]四川省骨科医院,四川成都610041

出　　处：《西部中医药》2022年第3期104-107,共4页Western Journal of Traditional Chinese Medicine

基　　金：国家科技支撑计划项目(2012BAK21B01)。

摘　　要：目的:探讨抗骨质疏松胶囊对绝经后骨质疏松症患者骨密度及骨代谢生化指标的影响。方法:将骨质疏松症患者80例随机分成观察组和对照组各40例。对照组予碳酸钙D3片、骨化三醇软胶囊及阿仑膦酸钠片治疗,观察组在对照组基础上加抗骨质疏松胶囊。治疗6个月后比较两组患者腰椎骨密度(bone mineral density,BMD)、髋部BMD及血清钙(Ca)、磷(P)、甲状旁腺激素(parathyroid hormone,PTH)、25-(OH)VitD、Ⅰ型胶原羧基端肽β特殊序列(β-C-terminal telopeptide of typeⅠcollagen,β-CTX)、Ⅰ型原胶原氨基端延长肽(propeptide of type 1 procollagen,PINP)、骨碱性磷酸酶(bone specific alkaline phos-phatase,BALP)、骨钙素(bone gla protein,BGP)。结果:治疗后两组患者Ca、P、PTH比较差异无统计学意义(P>0.05)。治疗后观察组患者腰椎BMD、髋部BMD、25-(OH)VitD、PINP、BALP、BGP较对照组高,β-CTX较对照度低,差异有统计学意义(P<0.05)。结论:抗骨质疏松胶囊可以影响绝经后骨质疏松症患者骨代谢生化标志物,通过促进骨形成、抑制骨吸收提高骨密度。Objective:To discuss the effects of anti-osteoporosis capsules on bone mineral density(BMD)and bone metabolism biochemical markers in patients with postmenopausal osteoporosis.Methods:Eighty patients were randomized into the observation group and the control group with 40 cases in each group.The control group was treated by calcium carbonate D3 tablets,calcitriol soft capsules and alendronate sodium tablets,and the observation group took anti-osteoporosis capsules based on the therapy the control group accepted.To compare lumbar BMD,sciatic BMD,the levels of serum calcium(Ca)and phosphorus(P),PTH,25-(OH)VitD,β-CTX,PINP,BALP and BGP between both groups after six months of treatment.Results:The difference presented no statistical meaning in the levels of Ca,P and PTH between both groups after treating(P>0.05).After the treatment,lumbar BMD,sciatic BMD,25-(OH)VitD,PINP,BALP and BGP of the observation group were higher than these of the control group,β-CTX was lower than that of the control group,and the difference had statistical meaning(P<0.05).Conclusion:Anti-osteoporosis capsules could influence bone metabolism biochemical markers in patients with postmenopausal osteoporosis,and it could raise BMD by promoting bone formation and inhibiting bone resorption.

关 键 词：骨质疏松症 绝经后 骨密度 骨代谢生化指标 

分 类 号：R681[医药卫生—骨科学]