文拉法辛联合前庭康复训练对外周性眩晕患者情绪及前庭功能的影响  

The effect of venlafaxine combined with vestibular rehabilitation training on emotion and vestibular function of patients with peripheral vertigo

作　　者：乔冰[1] 芦二永[1] 张超[1] 张慧[2] Qiao Bing;Lu Eryong;Zhang Chao;Zhang Hui(First author's address the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,Henan,China)

机构地区：[1]河南科技大学第一附属医院,河南洛阳471003 [2]郑州大学第二附属医院,河南郑州450000

出　　处：《临床心身疾病杂志》2022年第1期33-39,共7页Journal of Clinical Psychosomatic Diseases

基　　金：河南省医学科技攻关计划项目(编号201702093)。

摘　　要：目的探讨文拉法辛联合前庭康复训练对外周性眩晕患者情绪及前庭功能的影响。方法将203例外周性眩晕患者按照随机数字表法分为A组67例、B组68例、联合组68例。A组给予文拉法辛联合常规康复训练,B组给予帕罗西汀联合前庭康复训练,联合组给予文拉法辛联合前庭康复训练,观察6周。干预前及干预6周末比较3组前庭症状指数、WOLF运动功能测试量表、Berg平衡量表评分,比较3组感觉结构、姿势稳定性,比较3组汉密顿焦虑量表、汉密顿抑郁量表、眩晕障碍评定量表评分。结果干预6周末3组前庭症状指数各维度评分显著低于干预前(P<0.01),B组与联合组显著低于A组(P<0.01),3组WOLF运动功能测试量表及Berg平衡量表评分均显著高于干预前(P<0.01),B组与联合组显著高于A组(P<0.01)。干预6周末3组前后方向及左右方向前庭感觉参数较干预前显著升高(P<0.01),B组与联合组显著高于A组(P<0.01),3组稳定性系数及体质量分布指数较干预前显著降低(P<0.01),B组与联合组显著低于A组(P<0.01)。干预6周末3组汉密顿焦虑量表及汉密顿抑郁量表评分均较干预前显著降低(P<0.01),A组与联合组显著低于B组(P<0.01),3组眩晕障碍评定量表各维度分及总分均显著低于干预前(P<0.01),B组与联合组躯体及功能维度评分显著低于A组(P<0.01),A组与联合组情绪维度评分显著低于B组(P<0.01),A组与B组总分显著高于联合组(P<0.01)。结论文拉法辛联合前庭康复训练可改善外周性眩晕患者的前庭功能,提高姿势稳定性、运动功能、平衡能力,改善情绪及生活质量。Objective To investigate the effect of venlafaxine combined with vestibular rehabilitation training on emotion and vestibular function of patients with peripheral vertigo.Methods A total of 203 patients with peripheral vertigo were divided into group A(n=67),group B(n=68) and combined group(n=68) according to random number table method.Group A was given venlafaxine + conventional rehabilitation training,group B was given paroxetine+vestibular rehabilitation training,and the combination group was given venlafaxine combined with vestibular rehabilitation training for 6 weeks.The scores of vestibular symptom index(VSI),Wolf motor function test scale(WMFT) and Berg balance scale(BBS)of the three groups were compared before the intervention and at the end of 6 weeks of intervention.The sensory structure and postural stability of the three groups were compared,and the scores of Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD) and dizziness handicap inventory(DHI) were compared.Results At the end of 6 weeks after intervention,the scores of VSI in the three groups were significantly lower than those before intervention(P <0.01),group B and combined group were significantly lower than group A(P<0.01).The scores of WMFT and BBS in the three groups were significantly higher than those before intervention(P<0.01),group B and combined group were significantly higher than group A(P<0.01).At the end of 6 weeks after intervention,the vestibular sensory parameters in the anterior and posterior directions and left and right directions in the three groups were significantly higher than those before intervention(P<0.01),group B and combined group were significantly higher than group A(P<0.01).The stability coefficient(ST) and weight distribution index(WDI)of the three groups were significantly lower than those before intervention(P<0.01),group B and combined group were significantly lower than group A(P<0.01).At the end of 6 weeks after intervention,the scores of Hamilton anxiety scale(HAMA) and Hamilton depression scale

关 键 词：外周性眩晕 文拉法辛 前庭康复训练 前庭功能 焦虑 抑郁 

分 类 号：R255.3[医药卫生—中医内科学]