Recent advances of small-molecule fluorescent probes for detecting biological hydrogen sulfide  

作　　者：Lei Zhou Yu Chen Baihao Shao Juan Cheng Xin Li 

机构地区：[1]Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology,Hangzhou 310014,China [2]College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China

出　　处：《Frontiers of Chemical Science and Engineering》2022年第1期34-63,共30页化学科学与工程前沿（英文版）

基　　金：supported by China Postdoctoral Science Foundation(Grant No.2019M652053).

摘　　要：H_(2)S is well-known as a colorless,acidic gas,with a notoriously rotten-egg smell.It was recently revealed that H_(2)S is also an endogenous signaling molecule that has important biological functions,however,most of its physiology and pathology remains elusive.Therefore,the enthusiasm for H_(2)S research remains.Fluorescence imaging technology is an important tool for H_(2)S biology research.The development of fluorescence imaging technology has realized the study of H_(2)S in subcellular organelles,facilitated by the development of fluorescent probes.The probes reviewed in this paper were categorized according to their chemical mechanism of sensing and were divided into three groups:H_(2)S reducibility-based probes,H_(2)S nucleophilicity-based probes,and metal sulfide precipitation-based probes.The structure of the probes,their sensing mechanism,and imaging results have been discussed in detail.Moreover,we also introduced some probes for hydrogen polysulfides.

关 键 词：hydrogen sulfide fluorescent probe REDUCIBILITY NUCLEOPHILICITY copper sulfide precipitate hydrogen polysulfides 

分 类 号：X701[环境科学与工程—环境工程] TQ225[化学工程—有机化工]