High intercorneal symmetry in corneal biomechanical metrics  

作　　者：XiaoBo Zheng FangJun Bao Brendan Geraghty JinHai Huang AYong Yu QinMei Wang 

机构地区：[1]The Affiliated Eye Hospital of Wenzhou Medical University,Wenzhou,Zhejiang Province 325027,China [2]The Institution of Ocular Biomechanics,Eye Hospital,Wenzhou Medical University,No.270#Xueyuan West Road,Wenzhou City,Zhejiang Province 325027,China [3]School of Engineering,University of Liverpool,Liverpool L693GH,UK

出　　处：《Eye and Vision》2016年第1期58-65,共8页眼视光学杂志（英文）

基　　金：This study was supported by the Science and Technology Plan Project of Wenzhou Science and Technology Bureau(C20120009-04);Science Foundation of the Affiliated Eye Hospital of Wenzhou Medical University(YNCX201312,YNCX201405,YNZD201501);the National Natural Science Foundation of China(81300807).

摘　　要：Backgroud:To evaluate the symmetry of corneal biomechanical metrics,measured using an ocular response analyzer(ORA)and self-built corneal inflation test platform,in bilateral rabbit corneas and to investigate their relationship with physical intraocular pressure(IOPp).Methods:Twenty fresh enucleated eyes from ten rabbits were used for ex vivo whole ocular globe inflation.IOP was increased from 7.5 to 37.5 mmHg with 7.5 mmHg steps and biomechanical metrics were acquired using the ORA.At least 3 examinations were performed at each pressure stage.Two biomechanical metrics,corneal hysteresis(CH)and corneal resistance factor(CRF)were recorded and analyzed as a function of IOPp.Corneal specimens were then excised from the intact ocular globe and tested under inflation conditions up to 45.7 mmHg posterior pressure.The experimental pressure-deformation data was analyzed using an inverse modeling procedure to derive the stress-strain behavior of the cornea.Results:A comparison of corneal shape parameters showed no statistically significant difference(P>0.05)between bilateral eyes.Similarly,there were no statistically significant differences in values of CH,CRF and corneal stiffness(as measured by the tangent modulus,Et)between bilateral eyes(CH:F=0.94,P=0.54;CRF:F=4.42,P=0.35;Et:F=3.15,P=0.12)at different pressure levels.IOPp was highly correlated with CRF while the relationship with CH was less pronounced.Conclusions:An obvious interocular symmetry in biomechanical metrics is found in this research.IOP has been shown to have important influences on the value of CRF provided by ORA.

关 键 词：Intercorneal symmetry Corneal biomechanical metrics Corneal stiffness Ocular response analyzer 

分 类 号：R69[医药卫生—泌尿科学]