右美托咪啶对大鼠脑保护作用及其机制的研究进展  

Research Progress:Brain protection of Dexmedetomidine and its Mechanism in Rats

作　　者：刘洋[1] 胡金玲[1] Liu Yang;Hu Jinling(Emergency Department of the First Affiliated Hospital of Jiamusi University,Jiamusi 154000,China)

机构地区：[1]佳木斯大学附属第一医院急诊科,黑龙江佳木斯154000

出　　处：《广东化工》2022年第5期66-67,共2页Guangdong Chemical Industry

摘　　要：右美托咪啶(Dexmedetomidine DEX)是临床麻醉常用的镇静催眠药,其特点是高选择性且无呼吸抑制。临床应用可降低麻醉药品的用量及相关应激反应,提高手术成功率。目前,有越来越多的临床实验研究结果表明DEX可改善神经损伤,降低神经功能障碍的发生率,同时,大量的动物实验研究证实,DEX可通过降低兴奋性氨基酸活性、降低受损神经细胞钙超载、抗氧化应激、抑制炎症反应、抗神经细胞凋亡等多种机制起到脑神经保护作用。通过上述机制的综述,对DEX的脑保护作用有完整的认识,为该药的潜在价值提供理论支持。Dexmedetomidine is a sedative-hypnotic agent commonly used in clinical anesthesia, which is characterized by high selectivity and no respiratory inhibition.Clinical application can reduce the dosage of narcotic drugs and related stress response and improve the success rate of operation. At present, more and more clinical experimental results show that DEX can improve nerve injury and reduce the incidence of neurological dysfunction. At the same time, a large number of animal experimental studies have confirmed that, DEX can play a neuroprotective role in brain by reducing the activity of excitatory amino acids, reducing calcium overload of damaged nerve cells, resisting oxidative stress, inhibiting inflammatory response, and resisting nerve cell apoptosis. Through the review of the above mechanisms, we can have a complete understanding of the brain protective effect of DEX, and provide theoretical support for the potential value of DEX.

关 键 词：右美托咪啶 脑保护 Α2受体激动剂 细胞凋亡 炎症反应 

分 类 号：TQ[化学工程]