丹酚酸B治疗阿尔茨海默病的作用机制研究进展  

Recent progress of salvianolic acid B for treatment of Alzheimer’s disease

作　　者：李建 李强 李延峰 王洪权 LI Jian;LI Qiang;LI Yan-feng;WANG Hong-quan(Dept of Neurology, The Affiliated Hospital of Chifeng University, Chifeng Inner Mongolia 024000, China;Dept of Neurology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100050,China;Dept of Neurology&Aerospace Medical Center,Aerospace Center Hospital,Peking University Aerospace School of Clinical Medicine, Beijing 100049, China)

机构地区：[1]赤峰学院附属医院神经内科,内蒙古赤峰024000 [2]中国医学科学院/北京协和医学院北京协和医院神经内科,北京100050 [3]航天中心医院、北京大学航天临床医学院神经内科/航天医学中心,北京100049

出　　处：《中国药理学通报》2022年第4期487-491,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81260196,81450036);内蒙古自治区高等学校青年科技英才支持计划(No NJYT-17-B23);内蒙古自然科学基金项目(No 2018MS08046,2020MS08175,2021MS08131);航天医科科研基金资助项目(No 2020YK02);内蒙古草原英才计划项目(No)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是最常见的进行性神经退行性疾病,其特征是神经元丢失和认知功能障碍,该疾病严重影响老年人的生活,因此,探索AD的治疗具有重要的社会意义。丹酚酸B(salvianolic acid B,SAB)是源自丹参的主要水溶性活性天然化合物,对神经退行性疾病具有预防和治疗作用。体外和体内研究表明,SAB对AD具有改善作用。该研究旨在回顾SAB对AD治疗的实验研究,并阐述总结SAB对AD治疗的潜在分子机制,以期对后续研究起指导作用。Alzheimer’s disease(AD)is the most common progressive neurodegenerative disorder characterized byneuronal loss and cognitive impairment that harshly affect the elderly individuals.There are several hypotheses for the neurodegeneration process in AD.Salvianolic acid B(SAB)is the main water-soluble active ingredient of Salvia miltiorrhiza Bunge,which performs prophylactic and therapeutic activities against neurodegenerative diseases.Multiple lines of studies have shown that SAB displays ameliorative benefits in AD in several in vitro and in vivo studies.This study aims at reviewing experimental studies and describing the possible underlying molecular mechanisms by which SAB protects against AD.It is expected that this work may open the window to speed up the development of innovative anti-AD drugs originated from SAB and improve upcoming AD therapeutics.

关 键 词：阿尔茨海默病 Β-淀粉样蛋白 天然化合物 丹酚酸B 神经疾病防治 进展 

分 类 号：R284.1[医药卫生—中药学] R341[医药卫生—中医学]