提高2,3-BPG水平对组织氧气供应的影响及其药物研究进展  

The effect of increasing 2,3-BPG level on tissue oxygen supply and its drugs research progress

作　　者：郭茜文 李文斌 张汝学 王荣 赵安鹏 王子晗 GUO Qian-wen;LI Wen-bin;ZHANG Ru-xue;WANG Rong;ZHAO An-peng;WANG Zi-han(Pharmacy of the 940th Hospital of PLA Joint Logistics Surpport Force,Gansu Lanzhou 730050,China;School of Pharmacy,Gansu University of Traditional Chinese Medicine,Gansu Lanzhou 730050,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院药剂科,甘肃兰州730050 [2]甘肃中医药大学药学院,甘肃兰州730000

出　　处：《中国医院药学杂志》2022年第4期450-454,共5页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金(编号:82173738)。

摘　　要：初次进入高原的人由于环境氧分压降低,机体易产生一系列急性高原反应(acute mountain sickness, AMS)。国内对于抗缺氧药物的研究大多以改善AMS症状为主,从氧气利用解决缺氧问题的研究甚少。因此以释氧源头红细胞为着手点,通过增加红细胞中的2,3-二磷酸甘油酸(2,3-diphosphoglycerate, 2,3-BPG)浓度促进血红蛋白构象向T态转变,降低血红蛋白氧亲和力从而增加向组织释放氧气对解决缺氧问题具有重要意义。本文对直接或间接增加红细胞内2,3-BPG水平的影响途径及药物研究进展进行了综述,希望为AMS的预防和治疗提供新思路。People entering the plateau for the first time are prone to a series of acute mountain sickness(AMS)due to the decrease of environmental oxygen partial pressure.Domestic researches on anti-hypoxia drugs are mostly focused on improving AMS symptoms, and there are few researches on solving hypoxia problems by using oxygen.Therefore, it is of great significance to solve the problem of hypoxia by increasing the concentration of 2,3-diphosphoglycerate(2,3-BPG)in red blood cells at the source of oxygen release to promote the transformation of hemoglobin conformation to T state, reduce the oxygen affinity of hemoglobin and increase the release of oxygen to tissues.In this paper, we reviewed the influence of direct or indirect increase of erythrocyte 2,3-BPG level and the research progress of drugs, hoping to provide new ideas for the prevention and treatment of AMS.

关 键 词：2 3-二磷酸甘油酸 糖酵解 急性高原反应 限速酶 2 3-二磷酸甘油酸变位酶 

分 类 号：R979.9[医药卫生—药品]