肿瘤型人工关节假体的发展现状及优化策略  

Development status and optimization strategy of megaprosthesis prosthesis

作　　者：郭卫[1] Guo Wei(Musculoskeletal Tumor Center,Peking University People's Hospital,Beijing 100044,China)

机构地区：[1]北京大学人民医院骨与软组织肿瘤治疗中心,北京100044

出　　处：《中华解剖与临床杂志》2022年第3期129-137,共9页Chinese Journal of Anatomy and Clinics

摘　　要：肿瘤型人工关节的临床应用已趋于成熟,但松动、断裂及感染等相关并发症一直未得到很好解决,以至严重影响了患者整体的临床效果。近年来,生物材料、表面处理和生物力学等相关基础领域的研究进展为肿瘤型人工关节的设计改进提供了相应的理论基础。对肿瘤型人工关节的表面涂层改进和应用抗菌处理技术降低假体感染率、通过优化假体的结构设计改进固定方式,以及降低假体松动率、机械并发症等,是目前研究的主要方向。Although the application of megaprosthesis has maturely progressed,complications of aseptic loosening,breakage,and infection could not be satisfactorily solved and prominently influence the therapeutic effect and prognosis of patients.The development of biological materials,surface processing techniques,and biomechanics theoretically supports the improvement of megaprosthesis design.The present orientation which is focused on includes the improvement of surface coating technics for megaprosthesis,application of antibacterial processing which could decrease the occurrence of infection and amelioration of fixation by the optimization of structural design.

关 键 词：骨肿瘤 人工关节 关节置换 假体设计 

分 类 号：R318.17[医药卫生—生物医学工程]