Fluorescence Sensing of Glutathione Thiyl Radical by BODIPY-Modified β-Cyclodextrin  

作　　者：Zhixue Liu Xianyin Dai Qiaoyan Xu Xiaohan Sun Yu Liu 

机构地区：[1]College of Chemistry,State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China

出　　处：《Chinese Journal of Chemistry》2022年第4期493-499,共7页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(grant numbers 21807038,21772099,21861132001);by the China Postdoctoral Science Foundation(grant number 2019M651006).

摘　　要：Comprehensive Summary The fluorescence sensing of intracellular glutathione thiyl radical(GS·)is in great demand to seek the GS·-related pathophysiological events.Herein,boron-dipyrromethene(BODIPY)-modified β-cyclodextrin was developed for high-efficiency sensing of GS·,accompanied by a fast response time(t_(1/2)=218 s),with the detection limit of 468 nmol/L.Cell experiments indicated that the BODIPY-modified p-cyclodextrin could be applied to detect the GS· in live A549 cells.

关 键 词：Cyclodextrins Glutathione thiyl radical Biosensors BODIPY Radical reaction 

分 类 号：O65[理学—分析化学]