Synthesis,Crystal Structure and DNA-Binding Property of a New Cu(Ⅱ) Complex Based on 4-(Trifluoro-methyl)nicotinic Acid  

作　　者：SHAN Feng-Lin SONG Huan GAO Xue-Zhi LI Bing MA Xiao-Xia 单凤琳;宋欢;高学智;李冰;麻晓霞(State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering,Ningxia University,Yinchuan 750021,China;Department of Chemistry&Chemical Engineering,Ningxia University,Yinchuan 750021,China)

机构地区：[1]State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering,Ningxia University,Yinchuan 750021,China [2]Department of Chemistry&Chemical Engineering,Ningxia University,Yinchuan 750021,China

出　　处：《Chinese Journal of Structural Chemistry》2022年第2期57-63,I0008,共8页结构化学（英文）

基　　金：Supported by the National Natural Science Foundation of China (No. 21763022)。

摘　　要：A new complex[Cu_(1.5)(tfc)_(3)(H_(2)O)_(4)]·3H_(2)O (1,Htfc=4-(trifluoro-methyl) nicotinic acid) has been synthesized and characterized by X-ray single-crystal diffraction,elemental analysis,IR spectra and thermogravimetric analysis.1 belongs to orthorhombic system,space group Pccn with a=44.507(2),b=10.7710(6),c=11.7544(7)?,V=5634.9(6)?^(3),Z=1,D_(c)=1.803 mg·cm^(-3),F(000)=3068,μ=1.266 mm^(-1),the final R=0.0488and w R=0.1103 with I>2σ(I).The Cu(II) ion is coordinated by two N and two O atoms from different Htfc as well as two O atoms from two coordinated water molecules,forming a 0D motif with distorted octahedral geometry.The adjacent 0D units are linked into 2D structures through bridge connection coordination mode.In addition,the binding properties of the complex with CT-DNA were investigated by fluorescence and ultraviolet spectra.UVspectra indicate classical intercalation between the complex and CT-DNA.Moreover,the interactions between the ligand and the complex with CT-DNA were studied by Et Br fluorescence probe,which proved that these compounds bind to CT-DNA through an intercalation mode.The binding constants were 0.76 and 1.15 for Htfc and complex 1,which means 1 has stronger interaction with CT-DNA than Htfc.

关 键 词：4-(trifluoro-methyl)nicotinic acid crystal structure DNA 

分 类 号：O62[理学—有机化学]