Syntheses,Crystal Structures,Anticancer Activities and DNA-Binding Properties of the Dibutyltin Complexes Based on Benzoin Aroyl Hydrazone  

作　　者：JIANG Wu-Jiu TAN Yu-Jun MAN Jia-Tai TAN Yu-Xing 蒋伍玖;谭宇君;满家泰;谭宇星(Key Laboratory of Functional Metal-organic Compounds of Hunan Province,Key Laboratory of Functional Organometallic Materials,University of Hunan Province,Hunan Provincial Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiang Jiang River,College of Chemistry and Materials Science,Hengyang Normal University,Hengyang,Hunan 421008,China;Emergency Department,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]Key Laboratory of Functional Metal-organic Compounds of Hunan Province,Key Laboratory of Functional Organometallic Materials,University of Hunan Province,Hunan Provincial Engineering Research Center for Monitoring and Treatment of Heavy Metals Pollution in the Upper Reaches of Xiang Jiang River,College of Chemistry and Materials Science,Hengyang Normal University,Hengyang,Hunan 421008,China [2]Emergency Department,Xiangya Hospital,Central South University,Changsha 410008,China

出　　处：《Chinese Journal of Structural Chemistry》2022年第2期105-113,I0010,共10页结构化学（英文）

基　　金：Supported by the Scientific Research Fund of Hunan Provincial Education Department of China(No.19C0279);Functional Metal-organic Compounds of Hunan Science and Technology Innovation Team。

摘　　要：Dibutyltin benzoin benzoyl hydrazone complex Ⅰ[C_(6)H_(5)(O)C=N-N=C(Ph)CH(Ph)O]_(2)[(n-Bu)_(2)Sn]_(2)and dibutyltin benzoin salicyl hydrazone complex Ⅱ[2-(OH)-C_(6)H_(4)(O)C=N-N=C(Ph)CH(Ph)O]_(2)[(n-Bu)_(2)Sn]_(2)were synthesized and characterized by IR,^(1)H,^(13)C and^(119)Sn NMR spectra,HRMS,elemental analysis and thermal stability analysis,and the crystal structures were determined by X-ray diffraction.The crystal of complex I belongs to monoclinic system,space group P2_(1)/n with a=11.1942(8),b=10.4754(7),c=23.6700(17)?,?=101.529(2)?,Z=2,V=2719.6(3)?^(3),D_(c)=1.371 Mg·m^(–3),?(Mo Kα)=0.966 mm^(–1),F(000)=1152,R=0.0458and w R=0.1312.The crystal of complex II is of triclinic system,space group P1 with a=9.9960(4),b=11.2466(4),c=14.0509(5)?,α=69.4190(10)?,?=70.0600(10)?,γ=81.8090(10)?,Z=1,V=1389.69(9)?^(3),D_(c)=1.380 Mg·m^(–3),?(Mo Kα)=0.950 mm^(–1),F(000)=592,R=0.0284 and w R=0.0690.In vitro antitumor activities of both complexes were evaluated by CCK8 method against three human cancer cell lines(MCF7,NCI-H460 and Hep G2),and complex II exhibited better antitumor activity than I.The interaction between complexes and calf thymus DNA was studied by UV-vis,fluorescence spectroscopy and viscosity measurements.

关 键 词：DIBUTYLTIN complex synthesis crystal structure DNA 

分 类 号：O62[理学—有机化学]