Clickable rhodamine spirolactam based spontaneously blinking probe for super-resolution imaging  

作　　者：Zengjin Liu Ying Zheng Ting Xie Zihan Chen Zhenlong Huang Zhiwei Ye Yi Xiao 

机构地区：[1]Drug Research Center of Integrated Traditional Chinese and Western Medicine,Affiliated Traditional Chinese Medicine Hospital,Southwest Medical University,Luzhou 646000,China [2]State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024,China

出　　处：《Chinese Chemical Letters》2021年第12期3862-3864,共3页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos. 21421005, 21576040, 21776037, 22004011);China Postdoctoral Science Foundation (Nos. BX20200073 and 2020M670754);Dalian Science and Technology Innovation Fund (No. 2020JJ25CY014)。

摘　　要：Spontaneously blinking probe, which switches between dark and bright state without UV or external additives, is extremely attractive in super resolution imaging of live cells. Herein, a clickable rhodamine spirolactam probe, Atto565-Tet, is rationally constructed for spontaneously blinking after biorthogonal labelling and successfully applied to super resolution imaging of mitochondria and lysosomes.

关 键 词：Super resolution imaging Spontaneously blinking PKA Rhodamine spirolactam 

分 类 号：Q503[生物学—生物化学] O657.3[理学—分析化学]