A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions  

作　　者：Junwei Chen Na Wang Hongjuan Tong Chao Song Huijuan Ma Yajun Zhang Feng Gao Huan Xu Wei Wang Kaiyan Lou 

机构地区：[1]State Key Laboratory of Bioengineering Reactor.Shanghai Key Laboratory of New Drug Design,and Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science & Technology,Shanghai 200237,China [2]School of Pharmacy,Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province,Shaanxi Institute of International Trade&Commerce,Xi'an 712046,China [3]Department of Pharmacology and Toxicology and BIO5 Institute,University of Arizona,Tucson AZ 85721-0207,United States

出　　处：《Chinese Chemical Letters》2021年第12期3876-3881,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos. 21577037 and 21738002);the State Key Laboratory of Bioreactor Engineering, Shanghai Natural Science Fund (No. 20ZR1414700);Shanghai Sailing Program (No. 19YF1412500);Natural Science Basic Research Program of Shaanxi (No. 2019JQ-924);Key Breeding Program by Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province (No. 2019XT-1-03)。

摘　　要：Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked D-penicillamine based dual-modality fluorescent probe COU-DPA-1 for selective detection, differentiation, and detoxification of multiple heavy metal ions(Ag^(+), Hg^(2+), Cu^(2+)). The probe shows divergent fluorescence(FL)/circular dichroism(CD) responses via divergent bond-cleavage cascade reactions(metal ion promoted C-S cleavage and hydrolysis at two distinctive cleavage sites): FL “turn-off” and CD “turn-on” for Ag+(no hydrolysis), FL “turn-on” and CD “turn-off” for Hg^(+)(imine hydrolysis), and FL “self-threshold ratiometric” and CD “turn-off” for excess Cu^(2+)(lactone and imine hydrolysis), providing the first example of a fluorescence/CD dual-modality probe for multiple species with complimentary responses. Moreover, the bond-cleavage cascade reactions also lead to the formation of D-penicillamine heavy metal ion complexes for potential detoxification treatments.

关 键 词：Fluorescent probe Circular dichroism Heavy metal ions Dual-modality DETOXIFICATION Cascade reaction Divergent responses 

分 类 号：O657.3[理学—分析化学] R313[理学—化学]