拉贝洛尔联合低剂量阿司匹林治疗子痫前期的效果观察  

Clinical efficacy of labetalol combined with low-dose aspirin in treatment of preeclampsia

作　　者：郭迎迎 张凯[1] 刘秋瑾[1] Guo Yingying;Zhang Kai;Liu Qiujin(Department of Intensive Care,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第三附属医院重症医学科,450000

出　　处：《中国实用医刊》2021年第24期82-85,共4页Chinese Journal of Practical Medicine

摘　　要：目的观察拉贝洛尔联合低剂量阿司匹林治疗子痫前期(PE)的效果。方法前瞻选取2019年1月至2019年12月郑州大学第三附属医院确诊86例符合条件的PE患者,按照随机数字表法分为对照组和观察组,每组43例。对照组实施常规治疗联合拉贝洛尔治疗,观察组在对照组基础上联合低剂量阿司匹林治疗,两组均于治疗2周评估效果。治疗前、治疗2周,评估并比较两组血压和24 h尿蛋白水平;评估并比较两组各时点的凝血功能包括凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)及纤维蛋白原(FIB)、D-二聚体(D-D)水平;记录并比较两组不良妊娠结局;治疗期间,记录两组不良反应发生情况。结果治疗2周,两组舒张压、收缩压和24 h尿蛋白水平较治疗前降低,且观察组低于对照组(P<0.05);两组PT、APTT、TT水平较治疗前升高,FIB、D-D水平较治疗前降低,且观察组PT、APTT、TT水平高于对照组,FIB、D-D水平低于对照组(P<0.05);观察组总不良妊娠结局发生率低于对照组(P<0.05);两组不良反应发生率比较,P>0.05。结论拉贝洛尔联合低剂量阿司匹林更利于改善PE患者血压、24 h尿蛋白水平,更利于促进患者凝血功能恢复正常,减少不良妊娠结局风险,且不会增加不良反应发生率,安全可靠。Objective To observe the effect of labetalol combined with low-dose aspirin in the treatment of preeclampsia(PE).Methods Eighty-six eligible patients with PE diagnosed by the Third Affiliated Hospital of Zhengzhou University from January 2019 to December 2019 were prospectively selected,they were divided into control group and observation group by random number table method,with 43 cases in each group.The control group was treated with routine treatment combined with labetalol,and the observation group was treated with low-dose aspirin on the basis of the control group,the effect was evaluated at 2 weeks of treatment.Blood pressure and 24-hour urinary protein levels of the two groups were evaluated and compared before treatment and 2 weeks after treatment;the coagulation function including prothrombin time(PT),activated partial prothrombin time(APTT),thrombin time(TT),fibrinogen(FIB),D-Dimer(D-D)of the two groups were evaluated and compared at each time point;the adverse pregnancy outcomes were recorded and compared between the two groups;during the treatment,the adverse reactions of the two groups were recorded.Results After 2 weeks of treatment,the diastolic blood pressure,systolic blood pressure and 24-hour urinary protein levels in both groups were decreased than those before treatment,and those in the observation group were lower than those in the control group(P<0.05);the levels of PT,APTT and TT in both groups were all increased compared with those before treatment,while the levels of FIB and D-D were decreased compared with those before treatment,the levels of PT,APTT and TT in the observation group were higher than those in the control group,while the levels of FIB and D-D in the observation group were lower than those in the control group(P<0.05);the total incidence of adverse pregnancy outcomes in the observation group was lower than those in the control group(P<0.05);the incidence of adverse reactions was compared between the two groups(P>0.05).Conclusions Labetalol combined with low-dose aspirin is m

关 键 词：子痫前期 拉贝洛尔 阿司匹林 低剂量 

分 类 号：R714.244[医药卫生—妇产科学]