罗伊乳杆菌对肠屏障功能调节作用的研究进展  

New Developments in the Role of Lactobacillus Reuteri in Regulating Intestinal Barrier Function

作　　者：岑秋宇 庞日朝 胡晓敏 崔艳如 张安仁 CEN Qiuyu;PANG Rizhao;HU Xiaomin;CUI Yanru;ZHANG Anren(School of Health and Rehabilitation,Chengdu University of TCM,Chengdu 610075,China;Department of Rehabilitation Medicine,the General Hospital of Western Theater Command PLA,Chengdu 610083,China;Department of Rehabilitation Medicine,Shanghai Fourth People's Hospital Affiliated to Tongji University,Shanghai 200434,China)

机构地区：[1]成都中医药大学养生康复学院,四川省成都市610075 [2]中国人民解放军西部战区总医院康复医学科,四川省成都市610083 [3]同济大学附属上海市第四人民医院康复医学科,上海市200434

出　　处：《中国全科医学》2022年第15期1918-1922,共5页Chinese General Practice

基　　金：国家自然科学基金面上项目(81973927)。

摘　　要：肠屏障维持着肠道内环境的稳定,其正常功能依赖于肠道微生物群的动态调控。罗伊乳杆菌(L.reuteri)是目前已报道的天然存在于绝大多数脊椎动物和哺乳动物肠道内的乳酸菌,已被证实可通过多种途径影响肠屏障功能,保障机体健康。本文综述了L.reuteri对肠机械、化学、免疫、微生物屏障功能的影响及可能机制,以期为L.reuteri在相关疾病的临床应用中提供一定的理论依据和新思路。The intestinal barrier plays a role in maintaining the stability of the intestinal environment,which relies on the dynamic regulation of the intestinal microbiota.Lactobacillusreuteri(L.reuteri)is a lactic acid bacterium reported to be naturally present in the intestines of almost all vertebrates and mammals,and has been shown to affect the function of the intestinal barrier and safeguard the health of body through various pathways.This paper reviews the role and possible mechanisms of action of L.reuteri in regulating intestinal physical,chemical,immune and microbial barrier functions,with the aim of providing a theoretical basis and new ideas for the clinical application of L.reuteri in treating related diseases.

关 键 词：胃肠道微生物组 罗伊乳杆菌 肠屏障 综述 

分 类 号：R378.2[医药卫生—病原生物学]