乙醛脱氢酶2在射血分数保留型心力衰竭中影响作用的研究进展  

Research Progress on Influence of Aldehyde Dehydrogenase 2 on Heart Failure with Preserved Ejection Fraction

作　　者：李萍[1,2] 吴勇军 Li Ping;Wu Yong-jun(University of South China,Hengyang 421001,Hunan Province,China;Xiangtan Hospital Affiliated to University of South China,Hengyang 411101,Hunan Province,China)

机构地区：[1]南华大学,湖南衡阳421001 [2]南华大学附属湘潭医院,湖南湘潭411101

出　　处：《中国社区医师》2022年第7期6-8,共3页Chinese Community Doctors

摘　　要：射血分数保留型心力衰竭(HFpEF)约占心力衰竭患者的50%,其高发病率和高死亡率成为目前最具挑战性的临床综合征之一,其生理病理机制复杂,目前没有统一的定论。乙醛脱氢酶2(ALDH2)是醛脱氢酶的一种,位于线粒体内,负责乙醇的代谢,能够抑制机体氧化应激,维持线粒体的正常功能,通过调节心肌细胞肥厚、纤维化及炎症反应来延缓心力衰竭的进展。Heart failure with preserved ejection fraction(HFpEF)accounts for about 50% of patients with heart failure,and its high morbidity and mortality have become one of the most challenging clinical syndromes,the physiological and pathological mechanism is complex,and there is no clear conclusion.Aldehyde dehydrogenase 2(ALDH2)is a kind of aldehyde dehydrogenase,located in mitochondria,responsible for ethanol metabolism,inhibits oxidative stress in the body,maintains the normal function of mitochondria,and delays the progression of heart failure by regulating cardiac hypertrophy,fibrosis,and inflammation.

关 键 词：乙醛脱氢酶2 心力衰竭 线粒体 发病机制 

分 类 号：R541.6[医药卫生—心血管疾病]