不同妊娠时期游离三碘甲腺原氨酸/游离甲状腺素比值与妊娠糖尿病发病风险的相关性研究  

Correlation analysis between free triiodothyronine/free thyroid hormone ratio and onset risk of gestational diabetes at different gestational periods

作　　者：王娅敏 钱菊芬[1] WANG Ya-min;QIAN Ju-fen(Department of Gynaecology,Anji County Maternal and Child Health Care Hospital,Anji,Zhejiang 313300,China)

机构地区：[1]浙江省安吉县妇幼保健院妇科,浙江安吉313300

出　　处：《中国卫生检验杂志》2022年第4期465-468,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨不同妊娠时期FT_(3)/FT_(4)比值与妊娠糖尿病(GDM)发病风险的相关性。方法选取2019年1月—2021年1月本院行规律产检的孕妇400例,于孕早期和孕中期测定甲状腺功能,并于妊娠24周~28周行82 g葡萄糖耐量实验(OGTT),根据OGTT结果将孕妇分为正常对照组(n=226)和GDM组(n=174),分别比较在孕早期和孕中期2组FT_(3)/FT_(4)比值的差异,采用Logistic回归分析孕早期和孕中期FT_(3)/FT_(4)比值与GDM发生的关系,采用ROC曲线分析FT_(3)/FT_(4)比值对孕妇发生GDM的预测价值。结果GDM组孕早期(0.40±0.08 vs 0.28±0.06,P<0.05)和孕中期(0.56±0.10 vs 0.36±0.09,P<0.05)FT_(3)/FT_(4)比值均显著高于正常对照组;Logistic回归分析提示孕早期FT_(3)/FT_(4)比值和孕中期FT_(3)/FT_(4)比值均是GDM发生的独立危险因素;ROC曲线分析提示孕早期FT_(3)/FT_(4)比值对GDM的发生有较好的预测价值,曲线下面积为0.760(95%CI:0.738~0.783,P<0.001),优于孕中期FT_(3)/FT_(4)比值对GDM的预测价值。结论孕早期和孕中期2组FT_(3)/FT_(4)比值均与GDM发病风险密切相关,其中孕早期FT_(3)/FT_(4)比值对GDM的发生有更好的预测价值。Objective To investigate the correlation between free triiodothyronine/free thyroid hormone(FT_(3)/FT_(4))ratio and onset risk of gestational diabetes(GDM)at different gestational periods.Methods A total of 400 pregnant women did pregnancy check-up regularly in our study between January 2019 and January 2021.Thyroid function was determined in the early and mid stage of pregnancy.All participants underwent 82 g glucose tolerance test(OGTT)during 24-28 weeks.According to the result of OGTT,all pregnant women were divided into two groups:the control group(n=226)and GDM group(n=174).The differences of FT_(3)/FT_(4)were compared between two groups during the early and mid pregnancy.Logistic regression analysis was used to explore the relationship between FT_(3)/FT_(4)and GDM.ROC curve was used to analyze the predictive value of FT_(3)/FT_(4)ratio to GDM in pregnant women.Results The FT_(3)/FT_(4)ratios in the GDM group in the early(0.40±0.08 vs0.28±0.06,P<0.05)and mid(0.56±0.10 vs 0.36±0.09,P<0.05)pregnancy were significantly higher than those in the control group.Logistic regression analysis showed that FT_(3)/FT_(4)ratio in early pregnancy and FT_(3)/FT_(4)ratio in second trimester were independent risk factors for GDM.ROC curve analysis showed that the FT_(3)/FT_(4)ratio in early pregnancy had a predictive value for GDM,with the area under the curve was 0.760(95%CI:0.738-0.783,P<0.001),which was larger than the predictive value of FT_(3)/FT_(4)ratio in mid pregnancy.Conclusion The FT_(3)/FT_(4)ratios in the early and mid-pregnancy are closely related to the risk of GDM,and the FT_(3)/FT_(4)ratio in the early pregnancy has a better predictive value for the occurrence of GDM.

关 键 词：游离三碘甲腺原氨酸/游离甲状腺素比值 妊娠糖尿病 不同妊娠时期 发病风险 

分 类 号：R587.1[医药卫生—内分泌]