Cell-cycle length of medial ganglionic eminence progenitors contributes to interneuron fate  

作　　者：Ni Zong Min Wang Yinghui Fu Dan Shen Yong-Chun Yu 

机构地区：[1]Jing’an District Central Hospital of Shanghai,State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Institutes of Brain Science,Fudan University,Shanghai 200032,China

出　　处：《Protein & Cell》2022年第2期141-147,共7页蛋白质与细胞（英文版）

基　　金：This work was supported by grants from the Shanghai Natural Science Foundation(20ZR1403800)to Y.F.The project was also supported by the Natural Science Foundation of China(31930044,31725012);the Foundation of Shanghai Municipal Education Commission(2019-01-07-00-07-E00062);the Collaborative Innovation Program of Shanghai Municipal Health Commission(2020CXJQ01);the Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01).

摘　　要：Dear Editor,GABAergic interneurons contribute to cortical function by regulating the balance of activity.Malfunction of inhibitory interneurons has been associated with neuropsychiatric disorders(Hashimoto et al.2003;Marín 2012).The most striking feature of GABAergic interneurons is their diversity of cell types.Although fate-mapping studies have demonstrated the presence of spatially and temporally distinct progenitor domains for interneuron subclasses within the embryonic ventral telencephalon(Butt et al.2005;Inan et al.2012),the mechanisms of interneuron subtype-determination during development remain poorly understood.

关 键 词：MEDIAL CYCLE striking 

分 类 号：Q42[生物学—神经生物学]