神经影像学技术在类淋巴系统研究中的应用进展  

Recent advance in application of neuroimaging techniques in the glymphatic system

作　　者：董瑞 韩玉强 张富俊 夏天娇[1] 顾小萍[1] Dong Rui;Han Yuqiang;Zhang Fujun;Xia Tianjiao;Gu Xiaoping(Department of Anesthesiology,Affiliated Drum Tower Hospital,Medical School of Nanjing University,Nanjing 210008,China;Drum Tower Clinical College of Xuzhou Medical University,Nanjing 210008,China;Drum Tower Clinical Medical College of Jiangsu University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院麻醉科,南京210008 [2]徐州医科大学鼓楼临床学院,南京210008 [3]江苏大学鼓楼临床医学院,南京210008

出　　处：《中华神经医学杂志》2022年第1期96-101,共6页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(81730033、81701371、82001132);"十三五"强卫工程-重点人才项目(ZDRCA2016069);南京大学医学院研究生科研与实践创新计划项目(2021)。

摘　　要：类淋巴系统是维持大脑内环境稳定的重要流体动力学系统,亦是中枢神经系统疾病治疗干预的新靶点。类淋巴系统研究的关键在于对脑脊液示踪剂的微流体动力学分析。笔者现就MRI技术、双光子显微成像技术、近红外荧光成像技术和全颅宏观成像技术等多种神经影像学技术在类淋巴系统研究中的应用进展进行介绍,并总结其各自的技术优势,旨在为类淋巴系统的基础和临床研究提供方法学策略。The glymphatic system is a fluid dynamics network that is important for maintaining homeostasis of the brain,and it is also a new target for the treatment of various central nervous system diseases.The crucial point regarding research into the glymphatic system is the microhydrodynamics of the cerebrospinal fluid tracer.This review summarizes the emerging technologies,such as magnetic resonance technology,two photon microscopic imaging technology,near infrared fluorescence imaging technology,and transcranial macroscopic imaging,and summarizes its research applications and technical advantages to provide methodological strategies for basic and clinical research on glymphatic system function.

关 键 词：类淋巴系统 磁共振成像 双光子显微成像 近红外荧光成像 全颅宏观成像 

分 类 号：R551.2[医药卫生—血液循环系统疾病]