中药乳香中1个新的西松烷型二萜  

A new cembranoid diterpene from Olibanum

作　　者：陈志超 陈芳有 黄伟明 卞玉婷 罗永明[1] CHEN Zhi-chao;CHEN Fang-you;HUANG Wei-ming;BIAN Yu-ting;LUO Yong-ming(School of Pharmacy,Jiangxi University of Chinese Medicine y Nanchang 330004,China)

机构地区：[1]江西中医药大学药学院,江西南昌330004

出　　处：《中国中药杂志》2021年第24期6417-6421,共5页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(82060697);江西省“赣鄱英才555工程”项目(5251500119);江西中医药大学博士科研启动基金项目(2018BSZR003)。

摘　　要：运用MCI、硅胶、ODS和Sephadex LH-20柱色谱以及制备型高效液相等方法,从乳香的醇提物中分离得到了5个化合物,通过波谱数据和文献数据对比分别鉴定为(1S,3R,4S,7R,11S,12R)-1:12,4:7-二环氧西松烷-8(19)-烯-3,11-二醇(1)、boscartin A(2)、(+)-松脂素(3)、(+)-5-hydroxy-3,4-dimethyl-5-pentylfuran-2(5H)-one(4)、acerogenin A(5)。其中化合物1为新化合物,化合物3~5为首次从乳香中分离得到,化合物1的结构通过波谱学分析和X-射线单晶衍射的方法确定。对化合物1和2进行了PC12神经细胞毒性实验,结果显示化合物1和2均是安全性比较好的化合物。Five compounds were isolated from the alcohol extract of Olibanum by MCI,silica gel,ODS,and Sephadex LH-20 column chromatographies and preparative high-performance liquid chromatography(HPLC).On the basis of spectral data and literature data,the compounds were identified as:(1S,3R,4S,7R,11S,12R)-1:12,4:7-diepoxisonane-8(19)-ene-3,11-diol(1),boscartin A(2),(+)-resinolin(3),(+)-5-hydroxy-3,4-dimethyl-5-pentylfuran-2(5H)-one(4),and acerogenin A(5).Compound 1 is a new compound,and compounds 3-5 were isolated from Olibanum for the first time.The structure of compound 1 was determined by spectroscopic analysis and single-crystal X-ray diffraction.Compounds 1 and 2 were tested for PC12 neurotoxicity,and the results showed that they were both safe compounds.

关 键 词：乳香 化学成分 西松烷型二萜 神经细胞毒性 

分 类 号：R284.1[医药卫生—中药学]