Catalyst-free,direct electrochemical trifluoromethylation/cyclization of N-arylacrylamides using TfNHNHBoc as a CF_(3) source  

作　　者：Han Wang Yongbin Xie Yicheng Zhou Nannan Cen Wenbo Chen 

机构地区：[1]Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power,Shanghai University of Electric Power,Shanghai 200090,China [2]CAS Key Laboratory of Energy Regulation Materials,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Chemical Letters》2022年第1期221-224,共4页中国化学快报（英文版）

基　　金：supported by the Natural Science Foundation of Shanghai(No.20ZR1471600);the Science and Technology Commission of Shanghai Municipality(No.19DZ2271100);the Open Research Fund Program of CAS Key Laboratory of Energy Regulation Materials(No.ORFP2020–06)。

摘　　要：A new electrochemical strategy for trifluoromethylation/cyclization using TfNHNHBoc as a CF_(3)source was established.This approach was realized by the direct electrolysis of Tf NHNHBoc under external oxidantfree and catalyst-free conditions,and afforded various trifluoromethylated oxindoles with good functional group compatibility and broad substrate scope.Preliminary mechanistic studies show that the reaction proceeds by a radical process.

关 键 词：ELECTROLYSIS TRIFLUOROMETHYLATION CYCLIZATION TfNHNHBoc Radical process 

分 类 号：O621.25[理学—有机化学]