Synthesis of arylsulfonyl-substituted indolo[2,1-a]isoquinolin-6(5H)-one derivatives via a TBAI-catalyzed radical cascade cyclization  

作　　者：Shengxian Zhai Shuxian Qiu Shuai Yang Bingyan Hua Yongsheng Niu Chuchu Han Youzhu Yu Yuchao Li Hongbin Zhai 

机构地区：[1]College of Chemistry&Environmental Engineering,Anyang Institute of Technology,Anyang 455000,China [2]Department of Chemistry,Guangdong University of Education,Guangzhou 510303,China [3]State Key Laboratory of Chemical Oncogenomics and Key Laboratory of Chemical Genomics,Shenzhen Engineering Laboratory of Nano Drug Slow-Release,Shenzhen Graduate School of Peking University,Shenzhen 518055,China

出　　处：《Chinese Chemical Letters》2022年第1期276-279,共4页中国化学快报（英文版）

基　　金：the State Key Basic Research Program of the People’s Republic of China (No. 2018YFC0310900);National Natural Science Foundation of China (Nos. 21871018, 21801005, 21732001);Shenzhen Science and Technology Innovation Committee (Nos. KQTD20190929174023858, JCYJ20180504165454447);Industry and Information Technology Bureau of Shenzhen Municipality (No. 201806151622209330);Guangdong Science and Technology Program (No. 2017B030314002);Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions (No. 2019SHIBS0004);the National Ten Thousand Talent Program (the Leading Talent Tier) for the financial support;the Science and Technology Project of Henan Province (No. 202102310328);the Henan Postdoctoral Foundation;the Postdoctoral Innovation Base of Anyang Institute of Technology for financial support

摘　　要：We have developed a metal-free radical cascade reaction of N-substituted 2-aryl indoles with readily available sulfonyl hydrazides for the rapid construction of arylsulfonyl-substituted indolo[2,1-a]isoquinolin-6(5H)-one derivatives.With the TBAI–TBHP catalytic system,a broad series of structurally diverse indolo[2,1-a]isoquinolin-6(5H)-one derivatives were obtained in moderate to excellent yields.The reaction features mild reaction conditions,operationally easiness,scaled-up feasibility,and high functional-group-tolerance.

关 键 词：TBAI-catalyzed METAL-FREE Radical cascade CYCLIZATION Nitrogen-containing heterocycles Fused-indole derivatives 

分 类 号：O626[理学—有机化学]