Automated and remote synthesis of poly(ethylene glycol)-mineralized ZIF-8 composite particles via a synthesizer assisted by femtosecond laser micromachining  

作　　者：Miao Wu Lingling Xia Yucen Li Difeng Yin Jianping Yu Wenbo Li Ning Wang Xin Li Jiwei Cui Wei Chu Ya Cheng Ming Hu 

机构地区：[1]School of Physics and Electronic Science,East China Normal University,Shanghai 200241,China [2]State Key Laboratory of Precision Spectroscopy,School of Physics and Electronic Science,East China Normal University,Shanghai 200241 China [3]XXL–The Extreme Optoelectromechanics Laboratory,School of Physics and Electronic Science,East China Normal University,Shanghai 200241 China [4]State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra-intense Laser Science,Shanghai Institute of Optics and Fine Mechanics(SIOM),Chinese Academy of Sciences(CAS),Shanghai 201800,China [5]University of Chinese Academy of Sciences,Beijing 100049,China [6]Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education,School of Chemistry and Chemical Engineering,Shandong University,Ji'nan 250100,China

出　　处：《Chinese Chemical Letters》2022年第1期497-500,共4页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China(No.11674340);Key Project of the Shanghai Science and Technology Committee(No.18DZ1112700)。

摘　　要：Mineralization of the ZIF-8 in the presence of biomacromolecules has been demonstrated to be a general way for making bioentities@ZIFs composites.The ZIF-8 crystals permit controlled storage and utilization of the bioentities,thus can benefit drug delivery,cold-chain breaking etc.With the increasing needs on personal care and distributed manufacturing,automated synthesis controlled by a computer becomes the next challenge.In this work,we designed an automatic synthesis system to prepare PEG mineralized ZIF-8 composite particles.This system is based on flow chemistry with the microfluidic chips fabricated by femtosecond laser micromachining.The particles were synthesized and monitored automatically.Furthermore,this synthesizer could be extended for fabrication of vaccine particles under remote control through internet.

关 键 词：ZIF-8 Automatic synthesis Remote synthesis MOFs Vaccine particles Microfluidic chip Flow chemistry 

分 类 号：TB332[一般工业技术—材料科学与工程]