(±)-Pyriindolin with a 2,2'-bipyridine-spiro[furan-3,3'-indoline]chimeric skeleton from the endophytic Streptomyces albolongus EA12432  

作　　者：Mengmeng Lan Tongxu Cui Kaichun Xia Guodong Cui Yiwen Chu Peng Fu Weiming Zhu 

机构地区：[1]Key Laboratory of Marine Drugs,Ministry of Education of China,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China [2]Laboratory for Marine Drugs and Bioproducts,Pilot National Laboratory for Marine Science and Technology(Qingdao),Qingdao 266237,China [3]School of Pharmacy,Chengdu University,Chengdu 610106,China

出　　处：《Chinese Chemical Letters》2022年第1期508-510,共3页中国化学快报（英文版）

基　　金：financially supported by the National Key Research and Development Program of China(No.2019YFC0312504);the National Natural Science Foundation of China(Nos.41876172,U1906213)。

摘　　要：(±)-Pyriindolin(1)with a rare molecular backbone formed by fusing a 2,2'-bipyridine nucleus into a spiro[furan-3,3'-indoline]skeleton,was isolated from the Streptomyces albolongus EA12432.The constitution and the relative configuration of(±)-1 were determined by extensive spectroscopic analyses,^(13)C calculation and DP4+probability analysis.The absolute configurations of optically pure(+)-1 and(-)-1 which were obtained after a chiral high performance liquid chromatography(HPLC)separation were further identified by electronic circular dichroism(ECD)calculations.(+)-and(-)-Pyriindolins displayed moderate cytotoxicity against HCT-116 cell line with the half-maximal inhibitory concentration(IC_(50))values of 2.89±0.17μmol/L and 4.47±0.26μmol/L,respectively.

关 键 词：Pyrisulfoxins Spiroindolone Streptomyces sp. ENDOPHYTE Cytotoxicity 

分 类 号：TQ464.4[化学工程—制药化工]