滋养血管在自体动静脉内瘘静脉内膜增生中的作用  

Vasa vasorum and venous neointimal hyperplasia in autologous arteriovenous fistulas

作　　者：陈沁兰(综述) 许冬梅 孔祥雷(审校) CHEN Qinlan;XU Dongmei;KONG Xianglei(Shandong Provincial Qianfoshan Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250012,China;Department of Nephrology,Shandong Provincial Qianfoshan Hospital,Shandong University,Jinan 250014,China)

机构地区：[1]山东大学齐鲁医学院,济南250012 [2]山东大学附属千佛山医院肾病学科

出　　处：《肾脏病与透析肾移植杂志》2022年第1期90-94,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金青年基金(82000728);山东省千佛山医院国家自然科学基金培育基金(QYPY2019NSFC1008);齐鲁卫生与健康杰出青年人才项目。

摘　　要：自体动静脉内瘘(AVF)是终末期肾病血液透析患者的“生命线”。静脉流出道狭窄是导致AVF失功最常见的原因,其病理改变主要为新生内膜增生(NIH)。目前NIH发生机制尚未阐明。滋养血管位于血管壁的中外层,是由微小血管组成的网状结构,可为血管壁供氧及补充营养物质,同时排出代谢废物。本综述重点阐述滋养血管参与NIH发生发展的可能机制,旨在为AVF失功寻求新的理论解释,为其防治提供新的干预靶点。Autologous arteriovenous fistula(AVF)is the lifeline for hemodialysis patients with end-stage renal disease,and AVF failures are most often caused by venous stenotic lesions.Neointimal hyperplasia(NIH)is the main pathological change of venous stenotic lesions in failed AVFs,though its precise mechanism remains unclear.Vasa vasorum refers to the network of microvessels which penetrates the tunica adventitia and media of large blood vessels,supplying them with oxygen and nutrients and removing metabolic waste.This paper reviews the possible mechanisms of vasa vasorum participating in development of NIH to provide new theoretical explanations and new therapeutic targets for prevention and treatment of AVF failures.

关 键 词：滋养血管 终末期肾病 自体动静脉内瘘 新生内膜增生 

分 类 号：R54[医药卫生—心血管疾病]