中国移植器官保护专家共识(2022版)  

Chinese expert consensus on organ protection of transplantation(2022 edition)

作　　者：中国肝移植注册中心 国家肝脏移植质控中心 国家人体捐献器官获取质控中心 国家骨科与运动康复临床研究中心 中国医师协会器官移植医师分会移植器官质量控制专业委员会 中国医院协会器官获取与分配工作委员会 国家创伤医学中心器官保护专业委员会 郑树森 李建辉 徐骁[5] 王彦峰[6] 谢海洋[7] 陈静瑜[8] 董念国[9] Mitesh Badiwala Roberto Vanin Pinto Ribeiro 殷浩海 辛立明[12] 张浩[13] 张建政[13] 霍枫 杨家印 杨洪吉[16] 泮辉[7] 李绍光[13] 贾俊君[7] 俞浩[7] 梁涵 杨思佳 乔银标 罗佳 李浩宇 王浩[13] 刘鐘阳 张里程[13] 胡潇逸 吴昊[7] 胡逸青 China Liver Transplant Registry;National Center for Healthcare Quality Management in Liver Transplant;National Quality Control Center for Donated Organ Procurement;National Clinical Research Center for Orthopedics;Sports Medicine&Rehabilitation;Committee on Transplant Organ Quality Control;Branch of Organ Transplant Doctor;Zheng Shusen(不详;Division of Hepatobiliary and Pancreatic Surgery,Department of Surgery,Shulan(Hangzhou)Hospital,Key Laboratory of Combined Multi-organ Transplantation of National Health Commission,Key Laboratory of the Diagnosis and Treatment of Organ Transplantation,Research Unit of Collaborative Diagnosis and Treatment For Hepatobiliary and Pancreatic Cancer,Chinese Academy of Medical Sciences(2019RU019),Key Laboratory of Organ Transplantation,Hangzhou 310003,China;Jinan Microecological Biomedicine Shandong Laboratory,Jinan 250002,China)

机构地区：[1]不详 [2]树兰(杭州)医院肝胆胰外科,国家卫生与健康委员会多器官联合移植研究重点实验室中国医学科学院肝胆胰肿瘤诊治创新单元及器官移植诊治重点实验室(2019RU019),浙江省器官移植重点实验室,杭州310003 [3]济南微生态生物医学省实验室,济南250002 [4]树兰(杭州)医院 [5]浙江大学医学院附属杭州市第一人民医院 [6]武汉大学中南医院 [7]浙江大学医学院附属第一医院 [8]无锡市人民医院 [9]华中科技大学同济医学院附属协和医院 [10]Toronto General Hospital [11]海军军医大学附属长征医院 [12]上海大学 [13]解放军总医院第四医学中心 [14]解放军南部战区总医院 [15]四川大学华西医院 [16]四川省人民医院

出　　处：《中华消化外科杂志》2022年第2期169-184,共16页Chinese Journal of Digestive Surgery

基　　金：海南省重大科技计划项目(ZDKJ2019009);济南微生态生物医学省实验室科研项目(JNL-2022002A, JNL-2022023C);浙江省基础公益研究计划(LGF21H030006);中国医学科学院创新单元项目(2019-I2M-5-030);国家自然科学基金(81721091);国家传染病科技重大专项(2017ZX10203205)。

摘　　要：器官移植是治疗终末期脏器功能衰竭最有效的手段,公民逝世后自愿捐献器官已成为我国移植器官的唯一来源。在临床实践中,移植器官保护技术对提升移植器官质量,改善受者预后发挥重要作用。中国医师协会器官移植医师分会、中华医学会外科学分会移植学组及中国肝移植注册中心科学委员会组织专家,基于国内外移植器官保护的基础研究与临床实践,根据牛津循证医学证据分级和GRADE推荐意见系统,针对肝脏、肾脏、胰腺、小肠、心脏、肺脏移植器官编写了《中国移植器官保护专家共识(2016版)》(以下简称2016版共识)。2022年,在中国肝移植注册中心、国家肝脏移植质控中心、国家人体捐献器官获取质控中心、国家骨科与运动康复临床研究中心、国家创伤医学中心器官保护专业委员会等机构的支持下,结合近年来国内外器官移植及器官保护临床实践与研究进展进行总结,形成《中国移植器官保护专家共识(2022版)》(以下简称共识)。此共识重点更新了相关器官获取、保存、转运、质量评估在临床实践中的技术进展及相应循证医学研究证据。此外,增加了包括以肢体移植为主的复合组织移植内容。本共识中器官保护策略旨在促进临床器官移植工作科学、规范开展。Organ transplantation is the most effective treatment for end stage organ failure,and voluntary donation after citizen's death is the only source of transplanted organ in China.Clinically,transplantation organ protection technology plays a critical role in improving the quality of transplantation organs and the prognosis of recipients.On the basis of domestic and worldwide basic research and clinical practice and according to the Oxford evidence classification and GRADE system,the experts organized by Organ Transplantation Doctor Branch of Chinese Medical Doctor Association,Organ Transplantation Group in Surgery Branch of Chinese Medical Association and China Liver Transplant Registry Scientific Committee had compiled and published theChinese Expert Consensus on Organ Protection of Transplantation(2016 edition)(hereinafter referred to as the 2016 edition consensus)for liver,kidney,pancreas,small intestine,heart,lung transplantation organs.With the support of China Liver Transplant Registry,National Center for Healthcare Quality Management in Liver Transplant,National Quality Control Center for Donated Organ Procurement,National Clinical Research Center for Orthopedics,Sports Medicine&Rehabilitation and National Trauma Medical Organ Protection Committee and combined with recent domestic and worldwide clinical practice and research progress for organ transplantation and organ protection,theChinese Expert Consensus on Organ Protection of Transplantation(2022 edition)(hereinafter referred to as the consensus)has been formulated in 2022.This edition of the consensus focuses on updating the technical progress and evidence-based medicine of organ procurement,organ preservation,organ transport,and quality evaluation in clinical practice.Additionally,protection of composite tissue for transplantation,mainly including limb graft,has also been included.The organ protection strategy recommended in this consensus aims to promote scientific and standardized clinical organ transplantation work.

关 键 词：器官移植 器官保护 机械灌注 器官保存液 专家共识 

分 类 号：R617[医药卫生—外科学]