顺二醇类生物分子的硼亲和分子印迹研究进展  

Advances in boron affinity molecular imprinting of cis-diol-containing biomolecules

作　　者：刘佳[1] 任芳芳 郑文青 宋倩怡 贾文慧 包建民[1] 李优鑫[1] LIU Jia;REN Fangfang;ZHENG Wenqing;SONG Qianyi;JIA Wenhui;BAO Jianmin;LI Youxin(Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency,Collaborative Innovation Center of Chemical Science and Engineering,School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072)

机构地区：[1]天津市现代药物传递及功能高效化重点实验室,天津化学化工协同创新中心,天津大学药物科学与技术学院,天津300072

出　　处：《分析试验室》2022年第3期366-372,共7页Chinese Journal of Analysis Laboratory

基　　金：天津大学自主创新基金(2021XZY-0067)项目资助。

摘　　要：含顺二酚的分子,如糖类、糖苷和糖蛋白等,在糖组学、代谢组学和蛋白质组学等不同领域都有着至关重要的作用。但是这类样品分子通常存在于非常低丰度的环境中且与许多干扰化合物共存,给临床和生物学上的分离检测带来了巨大的困难。因此,开发建立对顺二醇类化合物简单高效的分离方法具有重要意义。分子印迹技术,是基于模拟生物体内抗原与抗体相互作用原理而发展起来的一种新兴技术,近年来因其特定的分子识别能力以及材料的稳定性和重复性而引起了广泛关注,也在顺二醇类化合物的分离方面得到了许多应用。本综述总结了在顺二醇类化合物的分子印迹方面的最新进展,并对其未来发展的方向和前景进行了讨论。Cis-diol containing compounds,such as saccharides,glycosides,and glycoproteins,play a vital role in the diverse fields of glycomics,metabolomics and proteomics.However,this kind of sample molecules usually exist in very low abundance environments and also co-exist with many interfering compounds,which brings great difficulties for clinical or biological isolation and detection.Therefore,it is of great significance to develop a simple and efficient separation method for cis-diol compounds.Molecular imprinting technology is a new technology developed based on the principle of simulating the interaction between antigens and antibodies.In recent years,it has attracted wide attention due to its specific molecular recognition ability,stability and repeatability.It has also been widely applied in the separation of cis-diol compounds.In this review,the latest advances in molecular imprinting of cis-diol compounds are summarized,and the future development of cis-diol compounds is also discussed.

关 键 词：顺二醇类分子 硼亲和 分子印迹 分离富集 综述 

分 类 号：R917[医药卫生—药物分析学]