中药厚朴及其有效成分厚朴酚与和厚朴酚抗真菌和病毒的药理作用研究进展  

Research Progress in Anti-fungal and Anti-viral Effects of Magnoliae Officinalis Cortex, Magnolol and Honokiol

作　　者：张明发[1] 沈雅琴[1] ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《抗感染药学》2021年第12期1724-1728,共5页Anti-infection Pharmacy

摘　　要：中药厚朴及其有效成分厚朴酚与和厚朴酚具有广谱的抗真菌作用。其作用机制可能是通过增加真菌细胞内活性氧的水平,破坏线粒体(降低线粒体膜电位)而诱导真菌细胞凋亡和坏死;或通过破坏真菌细胞壁和细胞膜,提高细胞的通透性而杀死真菌;抑或通过抑制真菌的黏附能力,以及生物被膜的形成和增厚,降低真菌的自我保护能力而抑杀真菌。体内外实验结果表明,和厚朴酚能增强氟康唑抗白假丝酵母的作用。厚朴、厚朴酚与和厚朴酚还具有广谱的抗病毒作用,其主要是通过抑制病毒在细胞内的复制,产生抗流感病毒、疱疹病毒、登革病毒、诺如病毒和草鱼呼肠孤病毒的作用,也可通过提高宿主细胞的抗病毒的免疫应答和抗氧化作用,抑制病毒在细胞内复制,产生广谱抗病毒的作用。该文综述了厚朴、厚朴酚与和厚朴酚的抗真菌、抗病毒作用。Magnoliae Officinalis Cortex and its active ingredients(magnolol and honokiol) have broad-spectrum anti-fungal effects. The mechanisms may be to induce apoptosis and necrosis of fungal cells by increasing the level of reactive oxygen species in fungal cells and destroying mitochondria(reducing mitochondrial membrane potential), and kill fungal cells by destroying the fungal cell wall and membrane to improve the permeability of cells or by inhibiting the adhesion ability of fungi and the formation and thickening of biofilm to reduce the self-protection ability of fungi.In vivo and in vitro honokiol improves the antibacterial action of fluconazole against Candida ablicans. Magnoliae Officinalis Cortex, magnolol and honokiol have broad-spectrum anti-viral effects. They produce the actions against Influenza virus, Herpes virus, Dengue virus, Norovirus and Grass carp reovirus by inhibiting virus replication in cells,and by improving immunoresponsiveness against virus and antioxidative capacity of host cells. This paper reviews the anti-fungal and anti-viral effects of Magnoliae Officinalis Cortex, magnolol and honokiol.

关 键 词：厚朴 厚朴酚 和厚朴酚 真菌 病毒 

分 类 号：R961[医药卫生—药理学]