50mg利凡诺用于中期妊娠羊膜腔穿刺引产术可行性  

Feasibility analysis of 50mg rivanol applied by amniocentesis in labor induction of mid-term pregnancy

作　　者：陈德军[1] 廉红梅[1] 熊俊[1] 李红英[1] 何明[1] 刘微微 CHEN Dejun;LIAN Hongmei;XIONG Jun;LI Hongying;HE Ming;LIU Weiwei(Maternal and Child Health Hospital of Hubei Province, 430070)

机构地区：[1]湖北省妇幼保健院,武汉430070

出　　处：《中国计划生育学杂志》2022年第1期28-31,共4页Chinese Journal of Family Planning

基　　金：湖北省自然科学基金计划(ZRMS2017001358)。

摘　　要：目的:分析小剂量利凡诺用于中期妊娠羊膜腔穿刺引产术的可行性。方法:2016年2月-2018年2月在本院因中期妊娠要求引产女性中根据自愿原则选择320例,按照入组时间顺序分组各160例,常规组给予常规剂量(100mg)利凡诺,小剂量组给予50mg利凡诺,比较两组引产情况、产后出血及疼痛情况及药物使用不良反应。结果:低剂量组腔内给药至产程发动时间(24.09±4.73h)、产程发动至胎儿娩出时间(7.54±3.37h)、总引产时间(31.63±4.51h),完全引产(78.1%)、不完全流产率(19.4%)、引产成功率(97.5%)、引产失败率(2.5%),产后2 h出血量(89.7±9.2ml)、产后出血持续时间(4.4±1.5d)、产后大出血率(1.3%)及分娩疼痛程度与常规组比较均未见差异(P>0.05);不良反应发生率(31.9%)与常规剂量组(27.5%)比较无差异(P>0.05)。结论:与常规剂量100mg利凡诺相比,50mg利凡诺应用于羊膜腔穿刺引产中引产时间、引产成功率、出血量、疼痛程度、药物不良反应均无明显差异。Objective:To analyze the feasibility of low-dose rivanol applied by amniocentesis in labor induction of mid-term pregnancy.Methods:From February 2016 to February 2018,320 women who required labor induction of mid-term pregnancy were selected and divided into two groups(160 cases in each group).The women in group A were treated with routine dose of rivanol(100mg)by amniocentesis,while the women in group B were treated with low-dose rivanol(50mg)by amniocentesis.The situations of labor induction and postpartum hemorrhage and pain,and adverse drug reactions rate of the women were compared between the two groups.Results:The time from luminal administration to labor initiation,the time from labor initiation to fetal delivery,the total labor induction time,the complete labor induction rate,the incomplete abortion rate,the successful labor induction rate,the failure labor induction rate,the blood loss,the duration of postpartum hemorrhage,and rate of postpartum hemorrhage of the women in group B were 24.09±4.73,7.54±3.37h,31.63±4.51h,78.1%,19.4%,97.5%,2.5%,89.7±9.2ml,4.4±1.5d,and 1.3%,respectively,which had no significant different from those of the women in group A.The pain degree during delivery of the women in group B had also no significant different from that of the women in group A(P>0.05).There was no significant difference in the incidence of adverse reactions(31.9%vs.27.5%)of the women between the two groups(P>0.05).Conclusion:There are no significant differences in the time from luminal administration to labor initiation,the success rate of labor induction,the blood loss,the pain degree during delivery,and the incidence of adverse reactions between the women with 100mg rivanol by amniocentesis and the women with 50mg rivanol by amniocentesis.

关 键 词：中期引产 羊膜腔穿刺引产 50mg利凡诺 效果 

分 类 号：R71[医药卫生—妇产科学]