精子DNA碎片指数与精液常规参数及精子运动参数的相关性分析  

Analysis of the correlation between the sperm DNA fragmentation index of men and the parameters of their conventional semen and sperm motility

作　　者：常椿欣 吴正沐[1] 王彦林[1] CHANG Chunxin;WU Zhengmu;WANG Yanlin(International Peace Maternity and Child Health Hospital,Institute of Birth Defects and Rare Diseases,School of Medicine,Shanghai Jiao Tong University,Shanghai Key Laboratory of Embryo Original Diseases,Shanghai,200030)

机构地区：[1]上海交通大学医学院附属国际和平妇幼保健院,上海交通大学医学院出生缺陷与罕见病临床研究院,上海市胚胎源性疾病重点实验室,200030

出　　处：《中国计划生育学杂志》2022年第1期102-105,111,共5页Chinese Journal of Family Planning

基　　金：上海市青年科技英才扬帆计划资助(19YF1452300)。

摘　　要：目的:探讨精子DNA碎片指数(DFI)与男性年龄、精液常规参数及精子运动参数的相关性。方法:检测616例男性精子DFI、精液常规参数及精子运动参数,根据DFI值分为3组(DFI<15%组、15%≤DFI<30%组、DFI≥30%组),分析不同组间参数差异及精子DFI与参数的相关性。结果:不同DFI组间前向运动精子率、不动精子总数、曲线速度(VCL)、直线速度(VSL)有差异(P<0.01)。DFI与年龄、不动精子总数等呈正相关关系(r=0.35、0.27),与前向运动精子总数、曲线速度(r=-0.42、-0.33)等呈负相关关系。结论:精子DFI与男性年龄以及部分精液常规参数和精子运动参数有相关关系,可以协同评估精子质量,用于指导临床治疗和预测辅助生殖的妊娠结局。Objective:To explore the correlation between the sperm DNA fragmentation index(DFI)of men and their age,conventional semen parameters,and sperm motility parameters.Methods:Sperm DFI,semen routine parameters,and sperm motility parameters of 616 men were detected.And these men were divided into three groups according to DFI values,which included DFI<15%group,15%≤DFI<30%group,and DFI≥30%group.The correlations between the difference of parameters of conventional semen and sperm motility of the men in different groups and their sperm DFI were analyzed.Results:There were statistically significant differences in the forward motile sperm rate,the total number of motile sperm,the curve velocity(VCL),and linear velocity(VSL)of the men among different DFI groups(P<0.01).Sperm DNA fragmentation index of the men was positively correlated with their age and total number of motile sperm(r=0.35,r=0.27),and was negatively correlated with their total number of forward motile sperm and VCL(r=-0.42,r=-0.33).Conclusion:There is correlation between the sperm DFI of men and their age,some conventional semen parameters,and sperm motility parameters.Thus,sperm DFI combined with conventional semen parameters and sperm motility parameters can be used to synergy evaluate the sperm quality,to guide clinical treatment,and to predict the pregnancy outcomes after assisted reproduction.

关 键 词：精子DNA碎片指数 精液常规参数 精子运动参数 相关性 

分 类 号：R69[医药卫生—泌尿科学]