不孕女性血清抗精子抗体、抗心磷脂抗体水平变化及临床意义  

Changes and clinical significance of the levels of serum anti-sperm antibody and anticardiolipin antibody of infertile women

作　　者：朱薇 刘春艳 邓强 ZHU Wei;LIU Chunyan;DENG Qiang(Guang'an Hospital, West China Hospital, Sichuan University, Guang'an, Sichuan Province, 638000)

机构地区：[1]四川大学华西广安医院,638000

出　　处：《中国计划生育学杂志》2022年第1期112-114,共3页Chinese Journal of Family Planning

摘　　要：目的:分析不孕血清抗精子抗体(AsAb)、抗心磷脂抗体(ACA)水平变化及其临床意义。方法:选取2018年7月-2020年6月本院收治的400例女性不孕患者为不孕组,同期体检健康的100例已育女性为对照组,采用酶联免疫吸附法行血清AsAb、ACA水平检测,比较两组及不孕组不孕类型、不同流产史女性血清AsAb、ACA表达差异。结果:不孕组血清AsAb(25.8%)、ACA(27.0%)阳性率均高于对照组(3.0%、4.0%),继发性不孕女性血清阳性率高于原发性不孕者,流产1次、2次、≥3次不孕者AsAb、ACA阳性率依次升高(均P<0.05)。结论:女性不孕患者血清AsAb、ACA水平表达升高,且在不孕类型及流产次数方面存在差异,提示临床应加强不孕女性血清AsAb、ACA水平检测,为临床病因诊断提供参考。Objective:To analyze the changes of and clinical significance of the levels of serum anti-sperm antibody(AsAb)and anticardiolipin antibody(ACAb)of infertile women,and to study their clinical significance.Methods:400 infertile women were selected in study group and 100 normal women who received physical examination were selected in control group from July 2018 to June 2020.The levels of serum AsAb and ACAb of the women in the two groups were detected by enzyme-linked immunosorbent assay(ELISA).The differences of the serum AsAb and ACAb levels of the women were compared between the two groups.In the study group,the differences of the serum AsAb and ACAb levels were compared among the women with different types of infertility and among the women with different abortion histories.Results:The positive rates of AsAb(25.8%)and ACAb(27.0%)of the women in the study group were significantly higher than those(3.0%and 4.0%)of the women in the control group.The positive rates of AsAb and ACAb of the women with the secondary infertility were significantly higher than those of the women with the primary infertility.The positive rates of AsAb and ACAb of the women with once,2,and≥3 times of abortions had increased in turn(P<0.05).Conclusion:The levels of serum AsAb and ACAb of infertile women increase,and which of the women with different types of infertility and different frequencies of miscarriage are different.It indicates that the detection of serum AsAb and ACAb levels should be enhanced for providing references of clinical etiological diagnosis of infertility women.

关 键 词：不孕女性 抗精子抗体 抗心磷脂抗体 

分 类 号：R71[医药卫生—妇产科学]