结核性胸膜炎患者伴发胸膜结核瘤的影响因素分析  

Analysis of influencing factors in patients with tuberculous pleurisy complicated with pleural tuberculoma

作　　者：李晔 刘晓宁 章鑫丽 沙巍[3] 卫卫[3] 尤青海[1] Li Ye;Liu Xiaoning;Zhang Xinli;Sha Wei;Wei Wei;You Qinghai(Dept of Respiratory and Critical Care Medicine, The First Affliated Hospital of Anhui Medical University,Hefei 230022;Dept of Tuberculosis, Anhui Chest Hospital,Hefei 230022;Dept of Tuberculosis, Shanghai Chest Hospital,Shanghai 200000)

机构地区：[1]安徽医科大学第一附属医院呼吸与危重症医学科,合肥230022 [2]安徽省胸科医院结核科,合肥230022 [3]上海市肺科医院结核科,上海200000

出　　处：《安徽医科大学学报》2022年第3期461-463,共3页Acta Universitatis Medicinalis Anhui

基　　金：国家科技重大专项基金(编号:2018ZX10722302-001-006)。

摘　　要：目的分析结核性胸膜炎患者伴发胸膜结核瘤的影响因素,为患者治疗方案制定提供科学依据。方法选取结核性胸膜炎患者作为研究对象,根据是否伴发胸膜结核瘤将所有研究对象分为病例组和对照组。使用自制调查问卷收集患者的临床资料和实验室指标。结果共纳入了276例结核性胸膜炎患者,年龄(39.22±18.12)岁,其中84例患者伴发了胸膜结核瘤。单因素分析结果显示,结核性胸膜炎患者积液量、注入尿激酶以及使用糖皮质激素是患者发生胸膜结核瘤的影响因素(P<0.05)。进一步的多因素分析结果显示,胸腔积液含量、注入尿激酶以及使用糖皮质激素与结核性胸膜炎患者胸膜结核瘤的发生存在统计学意义(分别P=0.003、<0.001、0.001)。结论胸腔积液含量、注入尿激酶以及糖皮质激素的使用可能对结核性胸膜炎患者胸膜结核瘤的发生产生影响。Objective To analyze the influencing factors of patients with tuberculous pleurisy complicated with pleural tuberculoma,and to provide scientific basis for the formulation of treatment plan.Methods Patients with tuberculous pleurisy were selected as the research subjects.All the subjects were divided into case group and control group according to whether they were accompanied by pleural tuberculosis tumor.Self-made questionnaires were used to collect clinical data and laboratory indicators of patients.Results A total of 276 patients with tuberculous pleurisy,with an average age of(39.22±18.12)years,were enrolled in this study,and 84 of them had complicated pleural tuberculoma.Univariate analysis showed that effusion volume,urokinase injection and glucocorticoid use were the influencing factors for the occurrence of pleural tuberculoma in patients with tuberculous pleurisy(P<0.05).Further multivariate analysis showed that pleural effusion content,urokinase injection and glucocorticoid use were statistically significant with the incidence of pleural tuberculoma in patients with tuberculous pleurisy(P=0.003,<0.001,0.001).Conclusion Pleural effusion content,urokinase injection,and the use of glucocorticoid may influence the occurrence of pleural tuberculoma in patients with tuberculous pleurisy.

关 键 词：结核性胸膜炎 胸膜结核瘤 影响因素分析 

分 类 号：R521.7[医药卫生—内科学]