Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2  

作　　者：Shuyuan Zhang Qingtai Liang Xinheng He Chongchong Zhao Wenlin Ren Ziqing Yang Ziyi Wang Qiang Ding Haiteng Deng Tong Wang Linqi Zhang Xinquan Wang 

机构地区：[1]The Ministry of Education Key Laboratory of Protein Science,Beijing Advanced Innovation Center for Structural Biology,Beijing Frontier Research Center for Biological Structure,School of Life Sciences,Tsinghua University,Beijing,China [2]Comprehensive AIDS Research Center and Beijing Advanced Innovation Center for Structural Biology,School of Medicine,Tsinghua University,Beijing,China [3]NexVac Research Center,Tsinghua University,Beijing,China [4]Microsoft Research Asia,Beijing,China [5]Protein Chemistry and Proteomics Facility Technology Center for Protein Research,Tsinghua University,Beijing,China [6]Center for Infectious Disease Research and Beijing Advanced Innovation Center for Structural Biology,School of Medicine,Tsinghua University,Beijing,China

出　　处：《Cell Research》2022年第3期315-318,共4页细胞研究（英文版）

基　　金：We thank the Tsinghua University Branch of China National Center for Protein Sciences(Bejing)for technical support(Cryo EM,Protein Chemistry and Proteomics Facility Technology Center);This work was supported by funds from the National Natural Science Foundation of China(32171202);Tsinghua Unlversity Spring Breeze Fund(2020Z99CFY031).

摘　　要：Dear Editor,SARS-CoV-2 belongs to the Sarbecovirus subgenus of betacoronaviruses and other members in this subgenus include SARS-CoV and coronaviruses mainly found in bats1.It is generally believed that like SARS-CoV and MERS-CoV,SARS-CoV-2 has a natural origin and was selected either in animal hosts before zoonotic transfer,or in humans following zoonotic transfer2.However,the molecular determinants for host expansion of SARS-CoV-2 from animal reservoirs to humans remain largely unclear.

关 键 词：RESERVOIRS belongs EVOLUTIONARY 

分 类 号：R373[医药卫生—病原生物学]