基于微流控血管模型的血流动力学实验教学平台建设  

Construction of hemodynamic experiment teaching platform based on microfluidic vasculature model

作　　者：杨雅敏 李韪韬[1] 董瑞 YANG Yamin;LI Weitao;DONG Rui(Department of Biomedical Engineering,Nanjing University of Aeronautics and Astronautics,Nanjing 211106,China)

机构地区：[1]南京航空航天大学生物医学工程系,江苏南京211106

出　　处：《实验技术与管理》2022年第2期119-123,共5页Experimental Technology and Management

基　　金：南京航空航天大学实验技术研究与开发项目(201905030005442);南京航空航天大学教师教学能力提升研究课题(YKF20006)。

摘　　要：微流控技术可以构建复杂的微通道网络结构,通过在微米尺度上对微流体进行定量调控,能够在体外模拟体内微血管中的血流情况。该文首先基于微流控芯片建立了微血管模型,然后结合激光散斑血流成像系统,建设了血流动力学实验教学平台,平台可以开设微血管结构设计、血流动力学数值模拟、体外微血管血流动力学等多种教学实验。平台针对依赖动物模型的相关实验产生的难以重复、缺少定量控制、实验耗时长等问题,提供了解决方案,拓展了微流控技术在实验教学中的应用,是培养学生良好的科研素质、实验操作技能和创新思维的重要途径。Complex microchannel network structure can be constructed based on microfluidic technology. By quantitatively regulating microfluidics on the micrometer scale, it can simulate the blood flow in the microvessels in vitro. This article first established a microvascular model based on a microfluidic chip, and then combined with a laser speckle blood flow imaging system to build a hemodynamic experimental teaching platform. Various experiments can be performed with the platform, including the design of the microvascular structure, the numerical simulation of the hemodynamic feature,and the in vitro study of the microvascular hemodynamics. The platform provides a solution to the problems of difficult repetition, lack of quantitative control and long experimental time-consuming caused by animal model-dependent experiments. It expands the application of microfluidic technology in experimental teaching and is an important way to cultivate students’ good scientific research quality,experimental operation skills and innovative thinking.

关 键 词：微流控技术 血流动力学 激光散斑成像 综合性实验 生物医学工程 

分 类 号：G642.423[文化科学—高等教育学]