补肾益气组方治疗原发性小儿遗尿症(下元虚寒型)随机对照临床研究  

A randomized controlled clinical study on the treatment of primary pediatric enuresis(Xiayuan deficiency and cold type)by Nourishing Kidney and Qi Recipe

作　　者：李战 顾申枫 李华[1] 崔庆科 LI Zhan;GU Shen-feng;LI Hua;CUI Qing-ke(Shanghai Children's Hospital,Shanghai 200040;Central Hospital of Shanghai Jing'an District,Shanghai 200040)

机构地区：[1]上海市儿童医院,上海200040 [2]上海市静安区中心医院,上海200040

出　　处：《湖北中医药大学学报》2022年第1期88-90,共3页Journal of Hubei University of Chinese Medicine

基　　金：上海市2020年度综合医院中西医结合专项(项目编号:ZHYY-ZXYJHZX-202011);上海市进一步加快中医药传承创新发展三年行动计划(2021-2023)项目(项目编号:ZY(2021-2023)-0206-07)。

摘　　要：目的观察补肾益气组方对下元虚寒型原发性小儿遗尿症(PPE)疗效。方法将我院105例下元虚寒型PPE患儿随机分为治疗组(66例)与对照组(39例)。对照组口服醋酸去氨加压素治疗,治疗组口服补肾益气组方治疗。两组治疗均持续12周。治疗结束时,比较两组的疗效,复发率,中医症候积分疗效,以及不良反应发生概率。结果治疗后,治疗组总有效率显著高于对照组(P<0.05)。治疗后3个月时,对照组复发率为50.00%,治疗组复发率为23.81%,差异具有统计学意义(P<0.05);治疗后6个月,对照组复发率为62.50%,治疗组复发率为28.57%,对照组复发率高于治疗组(P<0.05);两组遗尿、形寒肢冷、面白腰酸积分与治疗前比较差异均有统计学意义(P<0.05);两组之间治疗前后积分的差值比较差异有统计学意义(P<0.05),以治疗组治疗前后的积分差值为大;对照组不良反应发生率高于治疗组(P<0.05)。结论补肾益气组方治疗下元虚寒型PPE疗效显著,复发率低,不良反应少。Objective To observe the therapeutic effect of Nourishing Kidney and Qi Recipe on primary pediatric enuresis(PPE)of Xiayuan deficiency-cold type.Methods A total of 105 cases of PPE children with Xiayuan deficiency-cold type were randomly divided into treatment group(66 cases)and control group(39 cases).Compared with oral desmopressin acetate treatment,treatment group was treated with Nourishing Kidney and Qi Recipe.The treatment lasted for 12 weeks in both groups.At the end of treatment,the curative effect,recurrence rate,curative effect of TCM syndrome,and the probability of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of treatment group was higher than control group(P<0.05);3 months after treatment,the recurrence rate in control group was 50.00%,and that in treatment group was 23.81%,the difference was statistically significant(P<0.05);6 months after treatment,the recurrence rate in control group was 62.50%,and that in treatment group was 28.57%,and the difference was statistically significant(P<0.05).Enuresis,cold limbs,facial whiteness and backache scores,the differences in each group before and after treatment were statistically significant(P<0.05),and the differences between the two groups before and after treatment were statistically significant(P<0.05),the difference in treatment group was larger.The incidence of adverse reactions was higher in control group than treatment group(P<0.05).Conclusion Nourishing Kidney and Qi Recipe has a significant effect on PPE of Xiayuan deficiency and cold type,with low recurrence rate and few adverse reactions.

关 键 词：原发性遗尿症 小儿 下元虚寒 补肾益气 治疗效果 

分 类 号：R277.5[医药卫生—中医学]