腹腔镜卵巢打孔术对多囊卵巢综合征不孕患者卵巢功能及自然妊娠评估的影响  

Effect of laparoscopic ovarian perforation on ovarian function and evaluation of natural pregnancy in infertility patients with polycystic ovary syndrome

作　　者：卫甜媛 魏婉 李春燕[1] WEI Tian-yuan;WEI Wan;LI Chun-yan(Department of Obstetrics,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院产科,河南洛阳471000

出　　处：《黑龙江医药科学》2022年第1期21-23,共3页Heilongjiang Medicine and Pharmacy

基　　金：2019年度河南省医学科技攻关计划联合共建项目,编号:LHGJ201913282。

摘　　要：目的:探究腹腔镜卵巢打孔术(LOD)对多囊卵巢综合征(PCOS)不孕患者卵巢功能及自然妊娠评估的影响。方法:选取我院2019-03~2020-03收治的PCOS不孕患者86例,随机分为观察组和对照组各43例。对照组患者行传统腹腔镜下双侧卵巢楔形切除术(BOWR),观察组患者行LOD。对比两组患者术中情况;对比两组患者手术前及术后1月患者激素水平变化;对比两组患者术前及术后1年卵巢体积及功能变化;评估两组患者术后1年内的妊娠情况并统计患者术后并发症发生情况。结果:手术过程中,观察组患者出血量低于对照组,且手术时间短于对照组(P<0.05);术后1个月两组患者睾酮(T)、雌二醇(E_(2))、黄体生成素(LH)水平均有降低,卵泡刺激素(FSH)水平均有升高(P<0.05),但组间差异无统计学意义(P>0.05);术后1年两组患者的卵巢体积均有缩小,血清抗苗勒管激素(AMH)水平均有降低,但观察组相关指标均高于对照组(P<0.05),两组患者窦卵泡数均减少,且观察组少于对照组(P<0.05);术后1年内两组患者自然妊娠率及流产率差异无统计学意义(P>0.05)。结论:LOD治疗PCOS不孕能有效调节患者激素水平,改善卵巢功能,提升患者术后生育能力,与传统术式相比,LOD易操作、损伤小,且术后并发症少。Objective:To investigate the effect of laparoscopic ovarian perforation(LOD)on ovarian function and natural pregnancy evaluation in infertility patients with polycystic ovary syndrome(PCOS).Methods:A total of 86 infertility patients with PCOS treated in the First Affiliated Hospital of Henan University of Science and Technology from March 2019 to March 2020 were selected and randomly divided into observation group and control group(43 cases in each group).Patients in the control group received traditional laparoscopic bilateral ovariectomy(BOWR),and patients in the observation group received LOD.The intraoperative conditions of the two groups were compared.The changes of hormone levels before and 1 month after operation were compared between the two groups.The changes of ovarian volume and function were compared between the two groups before surgery and one year after surgery.The pregnancy status of patients in the two groups within 1 year after surgery was evaluated and the incidence of postoperative complications was analyzed.Results:During operation,the amount of blood loss in observation group was lower than that in control group,and the operation time was shorter than that in control group(P<0.05).One month after surgery,the levels of testosterone(T),estradiol(E_(2))and luteinizing hormone(LH)were decreased in two groups,while the levels of follicle stimulating hormone(FSH)were increased in two groups(P<0.05),but there was no statistical significance between groups(P>0.05).One year after surgery,the ovarian volume and serum anti-Mullerian hormone(AMH)level in two groups were decreased,and the related indexes in observation group were higher than control group,and the number of sinus follicles in two groups was decreased,and the observation group was less than control group,the differences were statistically significant(P<0.05).There was no significant difference in natural pregnancy rate and abortion rate between two groups within 1 year after surgery(P>0.05).Conclusion:LOD in the treatment of PCOS infertili

关 键 词：腹腔镜卵巢打孔术 多囊卵巢综合征 不孕 卵巢功能 自然妊娠 激素水平 

分 类 号：R711.6[医药卫生—妇产科学]