血清PGE2、NPY水平与癌性神经病理性疼痛患者阿片耐受指数的相关性  

Correlation between serum PGE2 and NPY levels and opioid tolerance index in patients with cancer neuropathic pain

作　　者：韩龙 刘大伟 HAN Long;LIU Da-wei(Department of Pain,Rushan People's Hospital,Rushan 264500,China)

机构地区：[1]山东省乳山市人民医院疼痛科,山东乳山264500

出　　处：《黑龙江医药科学》2022年第1期59-62,共4页Heilongjiang Medicine and Pharmacy

摘　　要：目的:观察血清前列腺素E2(PGE2)及神经肽Y(NPY)在癌性神经病理性疼痛(NP)患者中表达,并分析二者与阿片耐受指数(OTI)的关系。方法:选取2018-01~2020-09乳山市人民医院疼痛科收治的85例癌性NP患者为研究对象,患者均在本院接受阿片药物治疗,治疗周期91d;于入院时、治疗30d、60d、91d时评估NP患者疼痛程度[采用视觉模拟评分量表(VAS)评估],并检测患者各时点血清PGE2、NPY水平;根据治疗91d时VAS评分分组;计算各组患者OTI,分析不同时点血清PGE2、NPY水平与癌性NP患者OTI的关系。结果:85例癌性NP患者经评估,治疗30d、60d、91d,患者VAS评分均较入院时升高,且随着时间延长,VAS评分逐渐升高,治疗91d时升高最为显著(P<0.05);治疗91d时,85例癌性NP患者中,无轻度疼痛者,中度疼痛(中度组)55例,重度疼痛(重度组)30例;治疗30d、60d、91d,患者PGE2、NPY水平均较入院时升高,随着时间延长,两组PGE2、NPY水平逐渐升高,且重度组各时点PGE2、NPY水平高于中度组(P<0.05);相关性检验发现,不同时点血清PGE2、NPY水平与患者OTI、疼痛程度均呈正相关(r>0,P<0.05),且在入院时相关系数r最大。结论:血清PGE2、NPY在癌性NP患者中过表达,二者过表达与OTI存在一定联系。Objective:To investigate the expression of serum prostatiin E2(PGE2)and neuropeptide Y(NPY)in patients with cancer neuropathic pain(NP),and to analyze the relationship between the expression of serum prostatiin E2(PGE2)and neuropeptide Y(NPY)and opiate tolerance index(OTI).Methods:Eighty-five patients with NP cancer admitted to the Department of Pain,Rushan People's Hospital from January 2018 to September 2020 were prospectively selected as the study subjects.All patients received opioid therapy in our hospital,and the treatment period was 91 days.Visual analogue scale(VAS)was used to evaluate the pain degree of NP patients at admission,30,60 and 91 days of treatment,and the levels of serum PGE2 and NPY at each time point were detected.OTI in each group was calculated according to VAS score at 91 days of treatment,and the relationship between SERUM PGE2 and NPY levels and OTI at different time points was analyzed.Results:The VAS score of 85 patients with NP cancer increased after 30,60 and 91 days of treatment compared with admission,and the longer the treatment,the higher the VAS score was,the most significant increase was at 91 days of treatment,the difference was statistically significant(P<0.05).According to VAS score at 91 days of treatment,85 patients with NP cancer were divided into two groups:no mild pain,55 patients with moderate pain(moderate group),and 30 patients with severe pain(severe group).The levels of PGE2 and NPY in patients at 30,60 and 91 days after treatment were higher than those at admission,and the longer the treatment lasted,the higher the levels of PGE2 and NPY were in the severe group than in the moderate group at each time point,the differences were statistically significant(P<0.05).Correlation test showed that serum PGE2 and NPY levels were positively correlated with OTI and pain at different time points(R>0,P<0.05),and the correlation coefficient R was the largest at admission.Conclusion:Serum PGE2 and NPY are overexpressed in NP patients with cancer,and are positively correlated wi

关 键 词：癌性神经病理性疼痛 前列腺素E2 神经肽Y 阿片耐受指数 相关性 

分 类 号：R441.1[医药卫生—诊断学]