昆明地区2563例人群维生素D营养的状况  

Vitamin D Status of 2563 Subjects in Kunming

作　　者：赵滢[1] 苏艳丹[1] 唐睿珠[1] 段勇[1] 邵文萍[1] ZHAO Ying;SU Yandan;TANG Ruizhu;DUAN Yong;SHAO Wenping(Dept.of Clinical Laboratory,The 1st Affiliated Hospital of Kunming Medical University/Yunnan Province Clinical Research Center for Laboratory Medicine,Yunnan Key Laboratory of Laboratory Medicine,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院医学检验科/云南省医学检验临床医学研究中心/云南省检验医学重点实验室,云南昆明650032

出　　处：《昆明医科大学学报》2022年第4期19-25,共7页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(81760384);云南省临床检验诊断创新团队基金资助项目(202005AE160009)。

摘　　要：目的通过测定健康体检人群血液25-羟维生素D[25(OH)D]水平,以昆明地区为例分析目前云南高原地区维生素D水平状况并探讨分析其相关影响因素。方法收集在昆明医科大学第一附属医院进行体检的健康人群血清样本,分别按性别、季节和年龄进行分组。采用电化学发光免疫分析法检测血清25(OH)D水平。结果2563例体检者的25(OH)D的平均水平为(62.79±23.33)nmol/mL,维生素D正常、不足、缺乏率分别为26.06%、42.84%和31.10%。性别、季节和年龄对血清25(OH)D均有影响。女性维生素D水平明显低于男性(P<0.05),女性维生素D缺乏者也显著多于男性。秋季维生素D水平明显高于其他三季(P<0.05)。各年龄组间25(OH)D水平,差异有统计学意义(P<0.05)。结论云南高原地区人群存在不同程度的维生素D缺乏,与性别、季节和年龄相关。开展25(OH)D检查可以为临床评估、诊断、治疗维生素D缺乏所致相关代谢疾病提供重要参考依据。Objective By measuring the blood level of 25-hydroxyvitamin D[25(OH)D]in healthy population,taking Kunming area as an example,the present vitamin D level and its influencing factors in Yunnan Plateau were analyzed and discussed.Methods Serum samples were collected from cases who underwent health examination in the First Affiliated Hospital of Kunming Medical University.Subjects were grouped by sex,season and age.Serum 25(OH)D level was detected by electrochemical luminescence immunoassay.Results The average 25(OH)D level of 2563 subjects was(62.79±23.33)nmol/mL.The normal,insuffcient and deficient rates of vitamin D were 26.06%,42.84%and 31.10%,respectively.The results showed that gender,season and age all affected serum 25(OH)D.The vitamin D level in women was significantly lower than that in men(P<0.05),and the vitamin D deficiency in women was also significantly higher than that in men.There was statistical significance in25(OH)D levels in different seasons(P<0.05).The vitamin D level in autumn was significantly higher than that in other three seasons(P<0.05).The difference of 25(OH)D level among age groups was statistically significant(P<0.05).Conclusion Different levels of vitamin D deficiency existed in Yunnan Plateau area,which was related to gender,season and age.25(OH)D test can provide an important reference for clinical evaluation,diagnosis and treatment of metabolic diseases caused by vitamin D deficiency.

关 键 词：25-羟维生素D 昆明 性别 季节 年龄 

分 类 号：R591[医药卫生—内科学]