Effects of T-2 Toxin Exposure on Bone Metabolism and Bone Development of Mice  

作　　者：Cui Yi-long Cao Zheng Zhang Jian Song Miao Li Yan-fei 

机构地区：[1]College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China

出　　处：《Journal of Northeast Agricultural University(English Edition)》2022年第1期89-96,共8页东北农业大学学报（英文版）

基　　金：Supported by the National Natural Science Foundation of China(31872530)。

摘　　要：T-2 toxin is the most widespread mycotoxin in crops,feed and food,which poses a serious threat to body health.Bone is the main target tissue for T-2 toxin accumulation.Ingestion of food contaminated by T-2 toxin is the main cause of Kashin-Beck disease.However,the specific mechanism of bone damage caused by T-2 toxin is still unclear.In this study,a total of 40 male C57BL/6N mice were divided into four groups and orally treated with 0,0.5,1.0 and 2.0 mg·kg^(-1) body weight T-2 toxin for 28 days.The results showed that exposure to T-2 toxin led to weight loss,bone mineral density reduction and femoral structural damage of mice.In addition,osteoblast-mediated bone formation was inhibited,and osteoclast-mediated bone resorption was enhanced.Meanwhile,the levels of bone metabolism-related hormones including parathyroid hormone,calcitonin and 1,25-dihydroxyvitamin D3 were reduced.More importantly,it was found that the level of neuropeptide Y(a neurohormone)was decreased.These results provided a new perspetive for understanding the osteotoxicity of T-2 toxin.

关 键 词：T-2 toxin bone metabolism parathyroid hormone CALCITONIN 1 25-dihydroxyvitamin D3 neuropeptide Y 

分 类 号：S816.7[农业科学—饲料科学]